Spilanthol 25394-57-4

Spilanthol (Acmella Oleracea Extract) is the lead bioactive N-isobutylamide isolated from the flowers and aerial parts of Acmella oleracea (syn. Spilanthes acmella), a South American Asteraceae plant commonly known as Paracress or Toothache Plant. Thanks to its ability to reduce subcutaneous facial muscle contractions and smooth expression lines, it is widely marketed as a "natural herbal Botox alternative" in modern cosmetic science.

Key Performance Advantages:

1. Expression-line relaxation: Spilanthol acts on sensory nerve endings and facial micro-muscles, producing a localized, reversible relaxation that softens crow's feet, forehead lines, and perioral wrinkles. The effect is topical and non-invasive—distinct from botulinum toxin's mechanism;

2. Dual anti-wrinkle action: Beyond immediate muscle relaxation, Spilanthol stimulates fibroblast activity to support collagen and elastin synthesis, improving dermal architecture over time;

3. Gentle & well-tolerated: Typical use level 2%–5% in finished formulas. In China's Inventory of Existing Cosmetic Ingredients, the reference maximum is 2% for leave-on body products and 1% for eye-area products;

4. Versatile formulation compatibility: Available in water-soluble (hydroglycolic) and oil-soluble (CO₂) forms. Pairs synergistically with Acetyl Hexapeptide-8, hyaluronic acid, and retinol. Suitable for anti-aging serums, eye creams, lip plumpers, and "instant-lift" emulsions;

5. Multi-functional bioactivity: Exhibits anti-inflammatory, antioxidant, broad-spectrum antimicrobial, and local anesthetic (tingling) properties—extending its use to oral care (toothpaste, mouthwash) and nutraceutical applications;

6. Regulatory friendly: Recognized as safe by the CIR Expert Panel and European CosIng database; FEMA/EFSA GRAS status.