Product Information
Product name
Isavuconazole
CAS No.
241479-67-4
Molecular Formula
C22H17F2N5OS
Molecular Weight
437.473
Molecular Structure
Quality Standard
98% up by HPLC
Appearance
White to yellow
powder
COA of Isavuconazole
ITEMS
STANDARDS
RESULTS
Appearance
White to
yellow powder
Conforms
Identification
The peak position of T001-M9 in the test
solution was the same as that in the related solution.
Conforms
Solubility
Practically
insoluble in water，soluble
Conforms
Melting point
120℃~126℃
121.5℃~123.0℃
Specific
Optical Rotation
[α]D20：-25.0°~-34.0°
-29.1°
Related
substances
Any single
impurity≤0.5%
0.17%
Total impurity ≤1.0%
0.23%
Loss on drying
≤1.0%
0.09%
Assay
≥ 98%
99.77%
Conclusion
The above
items have been tested according with the Enterprise Standard for the product，the results
comply with Specifications .
Usage
Isavuconazole is
a new type of triazole antifungal drug. On the basis of retaining the potent
anti-Candida activity of the first-generation triazole drugs, it has enhanced
the activity against filamentous fungal infection and is a broad-spectrum
antifungal drug. Compared with other azoles, the special molecular structure of
isavuconazole sulfate (containing 2 chiral centers) enables the orientation of
the triazole ring to engage with the binding pocket of the fungal CYP51 protein,
thus giving it a broader antifungal spectrum , including fungi resistant to
azoles (such as itraconazole, voriconazole, and posaconazole), have good
antibacterial activity.
Tags :
241479-67-4
Isavuconazole
Isavuconazole powder
Isavuconazole API
Isavuconazole raw material
Isavuconazole manufacturer
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