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DL-Cloprostenol Sodium 55028-72-3

98% up, GMP, DMF

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Ceramide 100403-19-8

Cosmetic Grade

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[4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride Rabeprazole key intermediate 675198-19-3

99% up by HPLC

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8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one Clozapine intermediate 50892-62-1

99% up by HPLC

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L-Ergothioneine EGT 497-30-3

99.9% up by HPLC；99.99% by SGS

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L-Alanyl-L-Glutamine/Ala-Gln/ 39537-23-0

Product Information Product name L-Alanyl-L-Glutamine; Alanyl Glutamine; L-Ala-L-Gln; Ala-Gln CAS No. 39537-23-0 Molecular Formula C8H15N3O4 Molecular Weight 217.225 Quality Standard 98.5% up by HPLC Appearance White to almost-white crystal or crystalline powder COA Test Items Specifications Results Appearance White to almost-white crystal or crystalline powder White crystalline powder Specific optical rotation +9.5°~ +11.0° +10.6° ID(Physico-chemical) Positive Conforms Identification(IR) The IR spectrum of the sample corresponds to the IR spectrum of the RS Conforms pH 5.0 ~6.0 5.7 Appearance of solution Not more opalescent than reference suspension 1 Conforms Not more intensely coloured than reference solution Y1 Conforms Chlorides ≤0.02% Conforms Sulphates ≤ 0.02% Conforms Ammonium salt ≤ 0.08% Conforms Loss on Drying ≤ 0.5% 0.25% Sulphated Ash ≤ 0.1% 0.05% Iron ≤ 10ppm Conforms Heavy metals ≤ 10ppm Conforms Arsenic(AS2O3) ≤ 1ppm Conforms Related substances 1 Impurity I ≤ 0.2% 0.01% Impurity II ≤ 0.04% ND Impurity III ≤ 0.15% ND Impurity IV ≤ 0.05% ND Impurity V ≤ 0.05% ND Impurity VI ≤ 0.5% 0.03% Any Individual unspecified impurity≤ 0.10% 0.02% Methylene dichloride ≤ 600ppm ND Related substances 2 Impurity N ≤ 0.10% 0.04% Impurity G ≤ 0.10% ND Impurity H ≤ 0.10% ND Impurity I ≤ 0.10% ND Impurity M ≤ 0.10% ND Assay (on the anhydrous basis) 98.5%~101.0% 100.8% Residual solvents Methanol ≤ 3000ppm ND Bacterial Endotoxins < 0.05EU/mg Conforms Microbial Limit Total aerobe ≤ 1000cfu/g <10cfu/g Total Yeast and Mold Count ≤ 100cfu/g 5cfu/g Escherichia coli Not detected ND Conclusion It conforms to all the specification Usage L-Alanyl-L-Glutamine(Alanyl Glutamine) is a pharmaceutically optimized, stable dipeptide that serves as a superior delivery system for glutamine in the human body. It is specifically designed for use in clinical and therapeutic nutrition, particularly when the body is under severe metabolic stress and glutamine becomes a conditionally essential amino acid. This form solves the critical problem of free glutamine’s instability in aqueous solutions. Core Functions and Direct Clinical Applications of L-Alanyl-L-Glutamine: 1. Provides a Stable, Bioavailable Source of Glutamine. Primary Application: Parenteral Nutrition (PN) / Intravenous Formulations. Mechanism & Use: The dipeptide bond protects the glutamine molecule, allowing it to remain stable in intravenous (IV) bags during heat sterilization and storage. Once infused, it is rapidly cleaved in the blood to release bioavailable L-glutamine and L-alanine. This makes it an essential component of Total Parenteral Nutrition (TPN) for patients who cannot use their gastrointestinal tract. 2. Serves as the Primary Fuel for Intestinal Lining Cells (Enterocytes). Primary Application: Gut Health Support & Barrier Function. Mechanism & Use: Glutamine is the preferred energy source for the cells of the small intestine. Supplementation with L-Alanyl-L-Glutamine in critically ill, surgical, or oncology patients helps maintain intestinal mucosal integrity, support gut barrier function, and may reduce the risk of bacterial translocation from the gut into the bloodstream. 3. Acts as a Crucial Metabolic Substrate for Immune Cells. Primary Application: Immune Modulation in Critical Care. Mechanism & Use: Lymphocytes, macrophages, and other immune cells require glutamine for optimal function, especially during times of physiological stress. Providing this dipeptide in clinical nutrition protocols helps support immune system competence in patients with sepsis, major trauma, burns, or post-operatively. 4. Improves Nitrogen Balance and Protein Metabolism. Primary Application: Muscle Mass Preservation & Recovery. Mechanism & Use: During severe catabolic states, the body breaks down muscle protein. L-Alanyl-L-Glutamine helps shift the body’s nitrogen balance towards a more anabolic (building) state, reducing muscle protein breakdown (catabolism) and aiding in the preservation of lean body mass. Key Product Advantages of L-Alanyl-L-Glutamine 1. Superior Stability: Soluble and heat-stable for reliable inclusion in parenteral formulations. 2. High Bioavailability: Efficiently hydrolyzed to release active glutamine at the target site. 3. Therapeutic Efficacy: Directly addresses glutamine deficiency in critical illness.

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Cyclopentasiloxane/Cyclomethicone(D5) 541-02-6

99.0% up by HPLC

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α-Glucosylrutin 130603-71-3

Product Information Product name α-Glucosylrutin; alpha-Glucosylrutin CAS No. 130603-71-3 Molecular Formula C33H40O21 Molecular Weight 432.59 Appearance Yellow to yellowish brown powder COA Test Items Specifications Results CHARACTERS - Appearance Yellow to yellowish brown powder. Yellow powder. - Solubility Freely soluble in water and methanol, slightly soluble in ethanol (96%). Conforms IDENTIFICATION A. Infrared absorption spectrophotometry Comparison: Enzymatically Modified Rutin RS. Conforms B. UV/Vis absorption spectrophotometry UV spectrum of test solution should have a absorption maxima at wavelengths of approximately 255nm and 350nm. Conforms C. Examine the chromatograms obtained in the Assay by HPLC The principal peak in the chromatogram obtained with the test solution is similar in retention time to the principal peak in the chromatogram obtained with reference solution. Conforms TESTS - Appearance and colour of solution, 1.0g/10mL water Light yellow to yellow clear solution Light yellow clear solution - Loss on drying , 105℃×3h ≤ 5.0 % 2.5 % - Sulphated ash ≤ 0.60 % 0.49 % - Heavy metals, as Pb ≤ 20 ppm < 20 ppm - Elemental impurities ICH Q3D Conform -- Arsenic (As) ≤ 1.5 ppm < 0.01 ppm -- Cadmium (Cd) ≤ 0.5 ppm < 0.01 ppm -- Lead (Pb) ≤ 0.5 ppm < 0.05 ppm -- Mercury (Hg) ≤ 3.0 ppm < 0.01 ppm ASSAY, on dried substance - Quercetin glycosides, by HPLC ≥ 70.0 % 90.1 % - α-Monoglucosylrutin, by HPLC ≥ 50.0 % 69.5 % - As rutin, by UV/Vis ≥ 60.0 % 82.6 % PARTICLE-SIZE DISTRIBUTION Not less than 97% of the powder by mass passes through a number 180 sieve (80 mesh sieve). Not less than 97% of the powder by mass passes through a number 180 sieve (80 mesh sieve). RESIDUAL SOLVENTS ICH Q3C Conform - Methanol ≤ 3000 ppm 14 ppm - Ethanol ≤ 5000 ppm < 10 ppm MICROBIOLOGICAL TESTS - Total aerobic microbial count ≤ 103 CFU/g < 102 CFU/g - Total yeasts and moulds count ≤ 102 CFU/g < 10 CFU/g - Escherichia Coli Absent in 1 g Absent in 1 g CONCLUSION: THE TEST RESULTS CONFORM TO THE SPECIFICATION 50350-01. Usage Core Efficacy of α-Glucosylrutin α-Glucosylrutin, produced via enzymatic modification, surpasses standard rutin by fundamentally addressing its two major inherent deficiencies: extremely poor water solubility and relatively weak stability. The introduction of a hydrophilic glucosyl group results in a qualitative leap in its biological efficacy. 1. Exceptional Antioxidant Activity α-Glucosylrutin retains rutin's potent free radical-scavenging capacity and synergizes with vitamins C and E to form an "antioxidant network," providing multi-layered protection. Key Enhancement:Due to its excellent water solubility and cellular permeability, its intracellular antioxidant effect far exceeds that of rutin, enabling it to protect cells from oxidative stress damage more effectively. 2. Potent Photoprotective Effects (A Star Function) UV Absorption: Capable of absorbing UVB and partial UVA, acting as a physical sunscreen agent. Reduction of Photodamage: This represents its core application. It significantly inhibits UV-induced reactive oxygen species generation, matrix metalloproteinase (MMP) activation, and inflammatory factor release. This addresses the root causes to prevent photoaging, reduce collagen degradation, and inhibit pigmentation. Stabilization of Vitamin C: In skincare formulations, it markedly enhances the stability of L-ascorbic acid, preventing its oxidation and inactivation, making it an ideal partner in "Vitamin C morning routine" products. 3. Anti-Inflammatory and Soothing Properties By inhibiting inflammatory pathways such as NF-κB, it effectively mitigates skin irritation, redness, and inflammatory responses, making it suitable for sensitive skin care and reparative products. 4. Enhancement of Vascular Strength and Microcirculation It inherits rutin's ability to improve capillary fragility and enhance vascular elasticity. In oral supplements, it is used to address conditions like venous insufficiency and edema.

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Avatrombopag Maleate 677007-74-8

Assay ≥99.0% with Single Impurity ≤0.10% by HPLC, GMP, DMF/DML

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