Berberine hydrochloride 633-65-8

98% up by HPLC

CP2020/ GMP/ DML, WC ,COPP ,Kosher , Halal ,FDA No.

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Product Details

Product Information

Product name	Berberine hydrochloride
CAS No.	633-65-8
Molecular Formula	C₂₀H₁₈CLNO₄
Molecular Weight	371.82
Quality Standard	98% up by HPLC, DML, WC ,COPP ,Kosher , Halal ,FDA No.,produced in GMP condition
Appearance	Yellow crystalline powder,inodorous,extreme bitter

COA

Test Items	Specifications	Results
Appearance	Yellow crystalline powder,inodorous,extreme bitter	Conforms
Identification	Be positive reaction under test procedure (1)(2)(3)(4)(5)	Positive reaction
Other alkaloid	Not strong than major blotch of check reagent	Pass
Loss on drying	≤12.0%	11.36%
Residue on Ignition	≤0.2%	0.1%
Assay(Dried basis)	≥ 97.0%	98.53%
Total bacteria	≤1000 cfu/g	50cfu/g
Total mold	≤100 cfu/g	5 cfu/g
E.coli	Absent/g	Absent
Conclusion	It conforms to CP2005 quality standard.

Usage

1. What is Berberine Hydrochloride?

Berberine Hydrochloride is a yellow crystalline alkaloid derived from Phellodendron amurenseand Coptis chinensis. As a leading manufacturer in China, we offer two distinct grades tailored to meet the stringent requirements of both the pharmaceutical industry and the rapidly growing dietary supplement market. Our facility ensures consistent batch quality, strict impurity control, and full regulatory documentation support.

2.Primary Applications of Berberine HCL

We classify our Berberine HCL into two main categories to serve diverse industrial needs:

(1) Pharmaceutical Grade: Antibacterial & Cardiovascular APIs

Used for manufacturing prescription drugs and clinical preparations.

Application Area	Function & Mechanism	Typical Formulation
Gastrointestinal Infections	Inhibits bacterial DNA synthesis (e.g., E. coli, Shigella). Effective for bacterial dysentery and acute diarrhea.	Berberine Tablets, Capsules (OTC)
Cardiovascular Health	Anti-arrhythmic properties; helps stabilize heart rhythm and reduce myocardial excitability.	Compound Cardiac Tablets
Gynecological Health	Local anti-inflammatory and antimicrobial effects.	Vaginal Suppositories, Effervescent Tablets

(2) Nutraceutical Grade: Metabolic Health & Wellness

Used for formulating dietary supplements targeting metabolic syndrome and longevity.

Application Area	Function & Mechanism	Market Trend
Blood Sugar Management	Activates the AMPK pathway, improving insulin sensitivity. Often referred to as "Nature's Metformin".	High demand in the USA & EU markets.
Weight Management	Supports lipid metabolism and reduces adipose tissue accumulation. Featured in "Natural Ozempic" stacks.	Popular in fitness and weight-loss supplements.
Cholesterol Support	Assists in lowering LDL (bad cholesterol) and triglycerides.	Commonly combined with Red Yeast Rice.
Gut Health	Modulates gut microbiota by inhibiting harmful bacteria.	Used in prebiotic/probiotic blends.