Calcium L-5-Methyltetrahydrofolate/ L-5-MTHF-Ca/ 151533-22-1

99% up by HPLC, D-isomer not detected

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Product Information

Product name	Calcium L-5-Methyltetrahydrofolate
CAS No.	151533-22-1
Molecular Formula	C₂₀H₂₇CaN₇O₆
Molecular Weight	501.56
Process	Bio-enzyme process/ USP
Appearance	White to light yellowish crystalline powder

COA

Test Items	Specifications	Results
Appearance	White to light yellowish crystalline powder	White powder
Calcium	Should comply with calcium salt identification reaction	Conforms
Identification	IR: The infrared absorption spectrum of this product should be consistent with the absorption spectrum of the standard product.The positions of the absorption peaks in the group frequency region and the fingerprint region should correspond one to one.The deviation of the wave number below 1000cm^-1 should not exceed ±0.5%, and the deviation of other wave numbers should not exceed ±10 cm^-1.	Conforms
Identification	HPLC: In the chromatogram obtained under the content determination item, the retention time of the main peak of the test solution is consistent with the retention time of the main peak of the reference solution.	Conforms
Assay (on anhydrous base)	95.0% - 102.0%	98.8%
Water content	6.0% - 17.0%	14.7%
Calcium (on dry basis)	7.0% ~ 8.5%	8.2%
Mesh Count	80	Conforms
Related Substances	Impurity A ≤0.5%	0.04%
	Impurity B ≤1.0%	0.14%
	Impurity C+D ≤1.0%	0.05%
	Impurity E ≤0.5%	ND
	Impurity F ≤0.5%	ND
	Impurity G ≤0.5%	0.10%
	Impurity H ≤0.5%	ND
	Impurity I ≤0.5%	0.03%
	Impurity J ≤0.15%	0.04%
	Total impurities ≤2.5%	0.05%
Chloride	≤0.5%	0.01%
Elemental impurities	Boron ≤50mg/kg	ND
	Platinum ≤10mg/kg	ND
	Arsenic ≤1.5mg/kg	0.25mg/kg
	Lead ≤1.0mg/kg	ND
	Cadmium ≤0.5mg/kg	ND
	Mercury ≤1.5mg/kg	ND
Residual solvents	Ethanol ≤ 5000ppm	ND
	Isopropyl alcohol ≤ 5000ppm	ND
	Acetone ≤ 5000ppm	ND
Microbial limits	Total Plate Count ≤ 1000cfu/g	Conforms
	Yeast & Mold ≤ 25cfu/g	ND
	E.Coli, Salmonella, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Clostridium should not detected	ND
Conclusion	It conforms to all the USP-NF2024 standard.

Usage

Calcium L-5-MTHF-Ca is the biologically active form of Vitamin B9, widely used in:

1. Prenatal & Maternal Health: Supports fetal neural tube development. It is the preferred folate for women with MTHFR gene mutations.

2. Cardiovascular Health: Helps maintain healthy homocysteine levels already within the normal range.

3. Mood & Cognitive Support: Involved in the synthesis of neurotransmitters like serotonin and dopamine.

4. MTHFR Support Formulas: The only form of folate that bypasses the MTHFR conversion pathway.

5. Pharmaceuticals: Used in prescription medications (e.g., combined oral contraceptives with folate).

6. Food Fortification: Added to functional foods, beverages, and infant formulas (approved by EFSA).

FAQ:

Q1: Is Calcium L-5-Methyltetrahydrofolate the same as Folic Acid?

A: No. Folic acid is synthetic and requires conversion in the body. Calcium L-5-MTHF is the natural, bioactive form ready for immediate use.

Q2: What is the difference between CAS 151533-22-1 and CAS 26560-38-3?

A: CAS 151533-22-1 refers specifically to the calcium salt of (6S)-5-MTHF (the active form). CAS 26560-38-3 is a different calcium salt form of 5-MTHF. Always confirm CAS 151533-22-1 for supplement use.

Q3: Is this ingredient stable in formulations?

A: Calcium L-5-MTHF-Ca is sensitive to heat, light, and oxygen. Microencapsulated versions are recommended for dry blends and tablets to ensure shelf-life stability.

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