1. Basic information of Resveratrol:
Product Name: Resveratrol
Other Names: Giant Knotweed Extract
Appearance: Off-White to white fine powder
Specification: 50%, 98% up
Identification: TLC and HPLC comply
Plant: Giant Knotweed
Extraction Solvents: Ethano & Water
Detection Method: HPLC
CAS NO.: 501-36-0
2.Introduction of Resveratrol:
Resveratrol is a polyphenol compound mainly derived from peanut, grape (red wine), Giant Knotweed, mulberry and other plants. Resveratrol is a natural polyphenol with strong biological properties, also known as astragalus triphenol. It is a chemoprophytant for tumor, and also a chemoprophytant for reducing platelet aggregation, preventing and treating atherosclerosis and cardiovascular and cerebrovascular diseases.
Under natural conditions, resveratrol exists in two forms: free state and glycoside. The chemical structure of resveratrol and its glycosides also has two isomers, cis-res, trans-res, cis-pd and trans-trans-pd, respectively. The latter two forms release resveratrol under the action of glycosidase in the intestinal tract, and resveratrol in plants mainly exists in the form of trans. Studies have shown that the physiological activity of trans isomers is stronger than that of cis isomers.
(1) Anti-tumor effect
Resveratrol is a natural tumor chemoprophylaxis agent, which has good anti-cancer activity in the three stages of initiation, promotion and expansion of tumorigenesis, and can inhibit the cancer cells in each stage, the mechanism may be related to its anti-cyclooxygenase-1. Up to now, the academic circles have not reached a consensus on the specific mechanism of its anti-tumor effect.
(2) Effects on the cardiovascular system
Epidemiological studies have found that the French daily intake of animal fat, but the incidence of cardiovascular disease and mortality were significantly lower than other European countries, this phenomenon is called "the French paradox (French paradox)", this may be related to its daily a lot of drinking wine, and wine of resveratrol may is the main active protection factor.
With the increasing incidence of cardiovascular diseases year by year, the cardiovascular protective effect of resveratrol has become a research hotspot, which can play a cardiovascular protection role by reducing myocardial ischemia-reperfusion injury, inhibiting atherosclerosis and thrombosis formation, anti-inflammatory, antioxidant, vasodilatory and so on. Resveratrol at its physiological concentration (0.1 mol/L) dilates blood vessels, thereby lowering blood pressure and reducing the risk of cardiovascular disease.
(3) Anti-oxidation, anti-free radical effect
Resveratrol is a natural antioxidant in plants, and its antioxidant mechanism mainly includes scavenging or inhibiting free radical generation, inhibiting lipid peroxidation, and regulating antioxidant enzymes. Kimura et al. reported that at 1.3 g/mL, resveratrol can significantly inhibit the autolysis of red blood cells in rats and the oxidative hemolysis caused by H202, and inhibit the production of lipid peroxide in and out of the heart, liver, brain and kidney of mice. In recent years, people have paid extensive attention to the antioxidant and free radical scavenging functions of resveratrol, because this physiological metabolism involves many physiological diseases closely related to human health, such as atherosclerosis, Alzheimer's disease and viral hepatitis.
(4) Antibacterial effect
As a natural plant antitoxin, resveratrol has been recognized by people. When grapes and other plants are affected by fungal infection, ultraviolet radiation and other adverse conditions, the accumulation of resveratrol in the corresponding parts can cope with adverse conditions.
Li yongjun et al. used resveratrol to conduct in vitro antibacterial experiments on staphylococcus MSSA, MRSA and CONS. MIC90 of MSSA, MRSA and CONS was 0.512, 0.512 and 0.256 mg/mL, respectively, indicating that resveratrol had a strong antibacterial effect on Staphylococcus.
(5) Anti-aging effect
In 2003, Harvard University professor DavidSinclair and his team discovered that resveratrol can activate acetylase and increase the life span of yeast, which inspired people to research the anti-aging effect of resveratrol. So far, resveratrol has been shown to prolong the lives of yeast, nematode worms, fruit flies and lower fish.
(6) Estrogen effect
In 1997, Dr. Gehm B of the United States discovered that the chemical structure of resveratrol is very similar to the estrogen-diethyleneestrol, which can compete for the binding space of its receptors and activate the transcription of estrogen-responsive genes.
(7) Regulation of the immune system
Gao et al. observed the effects of different doses of resveratrol on immune function by establishing an immunosuppressive model in mice. The results showed that different doses of resveratrol could significantly increase the phagocytic rate of macrophages, hemolytic value of half of serum, the number of antibody-forming cells in the body, the transformation rate of lymphocytes and the degree of ear swelling of mice (type IV hypersensitivity of normal mice). In normal mice, resveratrol has no obvious effect on immune function, but can inhibit type IV hypersensitivity reaction.
(8) Other biological functions
With the development of studies on resveratrol, it has been found that resveratrol also has the functions of regulating immunity, anti-virus, anti-allergy and protecting liver. In addition, resveratrol can be used as an additive to drugs, alcohol or cosmetics, as a new beauty and health products to delay the aging of people, maintain skin moisture, remove sores, chloasma, etc.