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Apalutamide ARN509 956104-40-8

Apalutamide ARN509 956104-40-8

99% up by HPLC
  • Product Details

Product Information


Product name

Apalutamide / ARN-509

CAS No.

956104-40-8

Molecular Formula

C21H15F4N5O2S

Molecular Weight

477.442

Quality Standard

99% up by HPLC

Appearance

White powder


COA of Apalutamide


ITEMS

SPECIFICATION

RESULT

Appearance

White powder

Conforms

Solubility

Soluble in water or 1% acetic acid at a

concentration of ≥1mg/ml to give a clear,

colorless solution

Conforms

Related Substance

(by HPLC)

Total Impurities ≤ 1.0%

0.17%

Single impurity ≤ 0.2%

0.02%

Loss on drying

≤ 0.5%

0.3%

Assay (by HPLC)

99.0103.0%

99.8%%

Conclusion

It meets the enterprise standard.


Usage


Function of apalutamide

As a second-generation nonsteroidal androgen receptor inhibitory drug, apalutamide can prevent the fusion of androgen and receptors, and block the transfer of AR to the nucleus of cancer cells. In addition, apalutamide can also control androgen and promote the growth of cancer cells.


The safety and efficacy of apalutamide are based on a randomized clinical trial of 1,207 patients with non-metastatic, castration-resistant prostate cancer. Patients in the trial received apalutamide or placebo. All patients also received hormone therapy, either with a gonadotropin-releasing hormone (GnRH) analog, or with surgery to lower the amount of testosterone in the body (surgical castration). Median metastasis-free survival was 40.5 months for patients taking apalutamide, compared with 16.2 months for patients taking placebo. From the above experiments, we can see that the effect of apalutamide in the treatment of prostate cancer is very significant.


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