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Recombinant human copper, zinc-superoxide dismutase rh-Cu, Zn-SOD 9054-89-1 Recombinant human copper, zinc-superoxide dismutase rh-Cu, Zn-SOD 9054-89-1

Recombinant human copper, zinc-superoxide dismutase rh-Cu, Zn-SOD 9054-89-1
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1. Basic information of rh-Cu, Zn-SOD 9054-89-1:

Product name

Recombinant human copper, zinc-superoxide dismutase

                          (rh-Cu, Zn-SOD)

Other names

superoxide dismutase, SOD1

CAS No.:

9054-89-1

Appearance

White/light blue powder or floccule

Activity

5000-10000IU/mg,25000IU/mg

Resource

Escherichia coli (E. coli)

Purity

95% up by SDS-PAGE analysis

Mol. Wt.

17 kDa


2. Usage of rh-Cu, Zn-SOD 9054-89-1: 


Superoxide dismutase (SOD) is a category of metalloenzyme, extensively existing in all living organisms (e.g. animals, plants, microorganisms, etc.). Based on its metallicity, SOD is categorized into copper, zinc-SOD (Cu, Zn-SOD), manganese-SOD (Mn-SOD) and iron-SOD (Fe-SOD). SOD has a physiological significance that can convert toxic superoxide free radicals into hydrogen peroxide, it’s the primary substance to scavenge oxygen free radicals in living organisms. It has been demonstrated that there are up to 60 diseases directly related to oxygen free radicals and SOD level has been known as an illustrated indicator for aging and death. SOD can prohibit superoxide free radicals-induced damage at cellular level and locally repair damaged cells. It plays more and more important role in anti-oxidation in living organisms. SOD is one of components in cosmetic products, approved by Ministry of Health of the People's Republic of China, because it can delay aging, regulate immune response and blood lipid level, and prevent radiation.

3. Function of Cu, Zn-SOD(SOD1):


1. Cu, Zn-SOD(SOD1) binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrialintermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide.Hydrogen peroxide can then be broken down by another enzyme called catalase.
 
2. Cu, Zn-SOD (SOD1)has been postulated to localize to the outer mitochondrial membrane (OMM), where superoxide anions would be generated, or the intermembrane space. The exact mechanisms for its localization remains unknown, but its aggregation to the OMM has been attributed to its association with BCL-2. Wildtype SOD1 has demonstrated antiapoptotic properties in neural cultures, while mutant SOD1 has been observed to promote apoptosis in spinal cord mitochondria, but not in liver mitochondria, though it is equally expressed in both. Two models suggest SOD1 inhibits apoptosis by interacting with BCL-2proteins or the mitochondria itself.

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MORE_DETAIL Recombinant human copper, zinc-superoxide dismutase rh-Cu, Zn-SOD 9054-89-1

1. Basic information of rh-Cu, Zn-SOD 9054-89-1:

Product name

Recombinant human copper, zinc-superoxide dismutase

                          (rh-Cu, Zn-SOD)

Other names

superoxide dismutase, SOD1

CAS No.:

9054-89-1

Appearance

White/light blue powder or floccule

Activity

5000-10000IU/mg,25000IU/mg

Resource

Escherichia coli (E. coli)

Purity

95% up by SDS-PAGE analysis

Mol. Wt.

17 kDa


2. Usage of rh-Cu, Zn-SOD 9054-89-1: 


Superoxide dismutase (SOD) is a category of metalloenzyme, extensively existing in all living organisms (e.g. animals, plants, microorganisms, etc.). Based on its metallicity, SOD is categorized into copper, zinc-SOD (Cu, Zn-SOD), manganese-SOD (Mn-SOD) and iron-SOD (Fe-SOD). SOD has a physiological significance that can convert toxic superoxide free radicals into hydrogen peroxide, it’s the primary substance to scavenge oxygen free radicals in living organisms. It has been demonstrated that there are up to 60 diseases directly related to oxygen free radicals and SOD level has been known as an illustrated indicator for aging and death. SOD can prohibit superoxide free radicals-induced damage at cellular level and locally repair damaged cells. It plays more and more important role in anti-oxidation in living organisms. SOD is one of components in cosmetic products, approved by Ministry of Health of the People's Republic of China, because it can delay aging, regulate immune response and blood lipid level, and prevent radiation.

3. Function of Cu, Zn-SOD(SOD1):


1. Cu, Zn-SOD(SOD1) binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrialintermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide.Hydrogen peroxide can then be broken down by another enzyme called catalase.
 
2. Cu, Zn-SOD (SOD1)has been postulated to localize to the outer mitochondrial membrane (OMM), where superoxide anions would be generated, or the intermembrane space. The exact mechanisms for its localization remains unknown, but its aggregation to the OMM has been attributed to its association with BCL-2. Wildtype SOD1 has demonstrated antiapoptotic properties in neural cultures, while mutant SOD1 has been observed to promote apoptosis in spinal cord mitochondria, but not in liver mitochondria, though it is equally expressed in both. Two models suggest SOD1 inhibits apoptosis by interacting with BCL-2proteins or the mitochondria itself.
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