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Epidermal Growth Factor (rhEGF) 62253-63-8 Epidermal Growth Factor (rhEGF) 62253-63-8

Epidermal Growth Factor (rhEGF) 62253-63-8
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Basic information of Epidermal Growth Factor (rhEGF):

Name

Epidermal Growth Factor (rhEGF)

Alias

EGF,Recombinant human epidermal growth factor (rhEGF) ,cottony-stimulating factor, EGF

CAS NO.

62253-63-8

INCI Name

Human Oligopeptide-1

Endotoxin level

 less than 1EU/μg

Bioactivity

1.0x107 IU/mg up

Grade Standard

Cosmetic grade / 97% min


Use of Epidermal Growth Factor (rhEGF): 


EGF secreted by each of us, when we were in child times the secretion is the highest, and then it decreased with age increases. Particularly, After 22 years of age, reduced secretion was more pronounced. When we use cosmetics containing EGF, absorbed through the skin, added EGF of our skin exogenously, so that it can make our skin to restore the young state.

We use E.coli by genetic engineering expressed, produced high purity EGF by biological fermentation. It was named Recombinant human epidermal growth factor (rhEGF). rhEGF have same structure with Human epidermal growth factor (EGF), it is a 6.2kDa protein.EGF stimulates the proliferation and differentiation of epithelial cells from skin, the cornea, lung and tracheal tissue and the gastrointestinal tract. EGF also promotes the proliferation of fibroblasts and embryonic cells. Thus, EGF plays an important role in wound healing and organogenesis.

EGF is a highly efficient cell division factor with many other biological effects, which mainly includes: 
1. stimulating the growth and proliferation of skin, cornea and tracheal epithelium tissue in vivo. 
2. Accelerating the healing process of epidermis damage on skin, cornea, etc. 
3. Repressing the gastric acid excretion.
4. Accelerating the proliferation of epithelial cells in human and animals. 
5. Facilitating the biosynthesis of protein, RNA, DNA as well as metabolic activity in epidermal cells.
 
First of all, put the EGF dissolved in distilled water. Wait the temperature of cosmetic cream decreased to below 40 degrees Celsius, then put the dissolved solution into the cream, stir the cream to full blending them.

Use of Epidermal Growth Factor (rhEGF)


COA of Epidermal Growth Factor (rhEGF):

Items

Specification

Result

Assay

≥98.0%

98.2%

Activity unit

≥6.0×105IU/mg

7.50×105 IU

Identification test

Positive

Positive

 

 

Appearance

It is white and aerosols. Added into 1ml distilled water, it can solve quickly.

It should not contain insoluble matter seen by naked eyes.

It is white and aerosols. Added into 1ml distilled water, it can solve quickly.

It should not contain insoluble matter seen by naked eyes.

PH value

7.2±0.2

7.14

Water residue

≤3.0%

1.93%

Sterility test

No bacterial growth

No bacterial growth

Abnormal toxicity exp

The test animals have No abnormal reactions. They keep healthy, and have weight increase.

The test animals have No abnormal reactions. They keep healthy, and have weight increase.



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MORE_DETAIL Epidermal Growth Factor (rhEGF) 62253-63-8

Basic information of Epidermal Growth Factor (rhEGF):

Name

Epidermal Growth Factor (rhEGF)

Alias

EGF,Recombinant human epidermal growth factor (rhEGF) ,cottony-stimulating factor, EGF

CAS NO.

62253-63-8

INCI Name

Human Oligopeptide-1

Endotoxin level

 less than 1EU/μg

Bioactivity

1.0x107 IU/mg up

Grade Standard

Cosmetic grade / 97% min


Use of Epidermal Growth Factor (rhEGF): 


EGF secreted by each of us, when we were in child times the secretion is the highest, and then it decreased with age increases. Particularly, After 22 years of age, reduced secretion was more pronounced. When we use cosmetics containing EGF, absorbed through the skin, added EGF of our skin exogenously, so that it can make our skin to restore the young state.

We use E.coli by genetic engineering expressed, produced high purity EGF by biological fermentation. It was named Recombinant human epidermal growth factor (rhEGF). rhEGF have same structure with Human epidermal growth factor (EGF), it is a 6.2kDa protein.EGF stimulates the proliferation and differentiation of epithelial cells from skin, the cornea, lung and tracheal tissue and the gastrointestinal tract. EGF also promotes the proliferation of fibroblasts and embryonic cells. Thus, EGF plays an important role in wound healing and organogenesis.

EGF is a highly efficient cell division factor with many other biological effects, which mainly includes: 
1. stimulating the growth and proliferation of skin, cornea and tracheal epithelium tissue in vivo. 
2. Accelerating the healing process of epidermis damage on skin, cornea, etc. 
3. Repressing the gastric acid excretion.
4. Accelerating the proliferation of epithelial cells in human and animals. 
5. Facilitating the biosynthesis of protein, RNA, DNA as well as metabolic activity in epidermal cells.
 
First of all, put the EGF dissolved in distilled water. Wait the temperature of cosmetic cream decreased to below 40 degrees Celsius, then put the dissolved solution into the cream, stir the cream to full blending them.

Use of Epidermal Growth Factor (rhEGF)


COA of Epidermal Growth Factor (rhEGF):

Items

Specification

Result

Assay

≥98.0%

98.2%

Activity unit

≥6.0×105IU/mg

7.50×105 IU

Identification test

Positive

Positive

 

 

Appearance

It is white and aerosols. Added into 1ml distilled water, it can solve quickly.

It should not contain insoluble matter seen by naked eyes.

It is white and aerosols. Added into 1ml distilled water, it can solve quickly.

It should not contain insoluble matter seen by naked eyes.

PH value

7.2±0.2

7.14

Water residue

≤3.0%

1.93%

Sterility test

No bacterial growth

No bacterial growth

Abnormal toxicity exp

The test animals have No abnormal reactions. They keep healthy, and have weight increase.

The test animals have No abnormal reactions. They keep healthy, and have weight increase.


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