α-Glucosylrutin 130603-71-3

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Product Information

Product name	α-Glucosylrutin; alpha-Glucosylrutin
CAS No.	130603-71-3
Molecular Formula	C₃₃H₄₀O₂₁
Molecular Weight	432.59
Appearance	Yellow to yellowish brown powder

COA

Test Items	Specifications	Results
CHARACTERS
- Appearance	Yellow to yellowish brown powder.	Yellow powder.
- Solubility	Freely soluble in water and methanol, slightly soluble in ethanol (96%).	Conforms
IDENTIFICATION
A. Infrared absorption spectrophotometry	Comparison: Enzymatically Modified Rutin RS.	Conforms
B. UV/Vis absorption spectrophotometry	UV spectrum of test solution should have a absorption maxima at wavelengths of approximately 255nm and 350nm.	Conforms
C. Examine the chromatograms obtained in the Assay by HPLC	The principal peak in the chromatogram obtained with the test solution is similar in retention time to the principal peak in the chromatogram obtained with reference solution.	Conforms
TESTS
- Appearance and colour of solution, 1.0g/10mL water	Light yellow to yellow clear solution	Light yellow clear solution
- Loss on drying , 105℃×3h	≤ 5.0 %	2.5 %
- Sulphated ash	≤ 0.60 %	0.49 %
- Heavy metals, as Pb	≤ 20 ppm	< 20 ppm
- Elemental impurities	ICH Q3D	Conform
-- Arsenic (As)	≤ 1.5 ppm	< 0.01 ppm
-- Cadmium (Cd)	≤ 0.5 ppm	< 0.01 ppm
-- Lead (Pb)	≤ 0.5 ppm	< 0.05 ppm
-- Mercury (Hg)	≤ 3.0 ppm	< 0.01 ppm
ASSAY, on dried substance
- Quercetin glycosides, by HPLC	≥ 70.0 %	90.1 %
- α-Monoglucosylrutin, by HPLC	≥ 50.0 %	69.5 %
- As rutin, by UV/Vis	≥ 60.0 %	82.6 %
PARTICLE-SIZE DISTRIBUTION	Not less than 97% of the powder by mass passes through a number 180 sieve (80 mesh sieve).	Not less than 97% of the powder by mass passes through a number 180 sieve (80 mesh sieve).
RESIDUAL SOLVENTS	ICH Q3C	Conform
- Methanol	≤ 3000 ppm	14 ppm
- Ethanol	≤ 5000 ppm	< 10 ppm
MICROBIOLOGICAL TESTS
- Total aerobic microbial count	≤ 103 CFU/g	< 102 CFU/g
- Total yeasts and moulds count	≤ 102 CFU/g	< 10 CFU/g
- Escherichia Coli	Absent in 1 g	Absent in 1 g
CONCLUSION: THE TEST RESULTS CONFORM TO THE SPECIFICATION 50350-01.

Usage

Core Efficacy of α-Glucosylrutin

α-Glucosylrutin, produced via enzymatic modification, surpasses standard rutin by fundamentally addressing its two major inherent deficiencies: extremely poor water solubility and relatively weak stability. The introduction of a hydrophilic glucosyl group results in a qualitative leap in its biological efficacy.

1. Exceptional Antioxidant Activity

α-Glucosylrutin retains rutin's potent free radical-scavenging capacity and synergizes with vitamins C and E to form an "antioxidant network," providing multi-layered protection.

Key Enhancement:Due to its excellent water solubility and cellular permeability, its intracellular antioxidant effect far exceeds that of rutin, enabling it to protect cells from oxidative stress damage more effectively.

2. Potent Photoprotective Effects (A Star Function)

UV Absorption: Capable of absorbing UVB and partial UVA, acting as a physical sunscreen agent.

Reduction of Photodamage: This represents its core application. It significantly inhibits UV-induced reactive oxygen species generation, matrix metalloproteinase (MMP) activation, and inflammatory factor release. This addresses the root causes to prevent photoaging, reduce collagen degradation, and inhibit pigmentation.

Stabilization of Vitamin C: In skincare formulations, it markedly enhances the stability of L-ascorbic acid, preventing its oxidation and inactivation, making it an ideal partner in "Vitamin C morning routine" products.

3. Anti-Inflammatory and Soothing Properties

By inhibiting inflammatory pathways such as NF-κB, it effectively mitigates skin irritation, redness, and inflammatory responses, making it suitable for sensitive skin care and reparative products.

4. Enhancement of Vascular Strength and Microcirculation

It inherits rutin's ability to improve capillary fragility and enhance vascular elasticity. In oral supplements, it is used to address conditions like venous insufficiency and edema.