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Somatostatin acetate 38916-34-6

Somatostatin acetate 38916-34-6

98% up by HPLC, GMP
  • Product Details

Product Information


Product name

Somatostatin acetate

Alias

Somatostatina, Somatostatine, Somatostatinum, Somatostatin, cyclic, Somatostatin-14, Aminopan, Panhibin, Somiaton

CAS No.

38916-34-6

Molecular Formula

C76H104N18O19S2

Molecular Weight

1637.87

Molecule Structure

Quality Standard

98% up by HPLC, GMP

Appearance

White powder


COA of Somatostatin Acetate


Items

Specification

Results

Appearance

White Powder

Conforms

Purity(HPLC)

> 98%

99.57%

Specific optical rotation (anhydrous and acetic acid-free substance)

-37° to -47°

-41°

Solubility

freely soluble in water and in acetic acid, practically insoluble in methylene chloride

Conforms

Related substances (HPLC)

Total impurities: NMT 2.0%
Any impurity: NMT 1.0%

1.3%

0.3%

Water (Karl Fischer)

NMT 8.0 %

6.5%

Acetic acid (HPLC)

3.0% to 15.0 %

8.7%

Bacterial endotoxins

< 10IU/mg

Conforms

Assay (anhydrous and acetic acid-free substance)

95.0% to 104.0%

99.34%

Conclusion

Complies with the standard.


Usage


Function of Somatostatin Acetate

Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation through its interaction with G protein.


① It can inhibit the secretion of growth hormone, thyroid stimulating hormone, insulin and glucagon.

②It can inhibit the secretion of gastric acid stimulated by the test meal and 5-peptide gastrin, and can inhibit the release of pepsin and gastrin.

③It can significantly reduce visceral blood flow, reduce portal vein pressure, reduce blood flow and pressure of collateral circulation, and reduce liver blood flow.

④Reduce the secretion of the pancreas and the secretion of the small intestine and gallbladder, reduce enzyme activity, and have a protective effect on pancreatic cells.

⑤ It can affect the absorption and nutritional function of the gastrointestinal tract.


Application of Somatostatin Acetate

Somatostatin Acetate can be used for severe and acute gastric and duodenal ulcer bleeding; acute erosive or hemorrhagic gastritis severe and acute bleeding; prevention of post-pancreatic complications after pancreatic surgery; inhibition of pancreas and Adjuvant treatment for severe secretion of leaky duct after upper small intestine surgery; regulating human differentiated gastric cancer cell lines

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