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Oxytocin Acetate 50-56-6

Oxytocin Acetate 50-56-6

98% up by HPLC, USP, EP, CEP
  • Product Details

Product Information


Product name

Oxytocin Acetate

CAS No.

50-56-6

Molecular Formula

C43H66N12O12S2

Molecular Weight

1007.33

Molecule Structure


Quality Standard

98% up by HPLC, USP/EP, CEP

Appearance

White powder


COA of Oxytocin Acetate


Items

Specification

Results

Appearance

White powder

Conforms

Solubility

Soluble in water or 1% acetic acid at a concentration of ≥1mg/ml to give a clear, colorless solution

Conforms

Identity by HPLC

The retention is same with the reference substance

Conforms

Amino acid composition

gly:0.851.10

pro:0.851.10

leu:0.851.10

cys:1.652.20

asn:0.851.10

gln:0.851.10

ile:0.851.10

tyr:0.851.10

1.02

1.06

1.01

1.88

0.96

1.01

0.99

1.02

pH

3.06.0

5.16

Specific optical rotation

c=1,1%hac

-21.2°

Purity

≥98.0%

99.12%

Related substance(by hplc)

total impurities(%)≤2.0%

largest single impurity(%)≤1.0%

0.88%

0.55%

Acetate content(by hplc)

≤12.0%

6.7%

Water

≤8%

5.7%

Peptide content (n%)

≥80.0%

87.6%

Bacterial endotoxins

≤70iu/mg

Conforms

Residual organic solvents

acetonitrile ≤0.041%(by gc)

dmf ≤0.088%(by gc)

meoh ≤0.3% (by gc)

tfa ≤0.1% (by hplc)

dcm ≤0.06% (by gc)

mecn ≤0.041% (by gc)

Conforms

Assay

95%105%

99.3%

Conclusion

Complies with the standard.


Usage


Function of Oxytocin Acetate

Oxytocin acetate is a peptide hormone, secreted by the posterior pituitary gland, synthesized by the paraventricular nucleus and supraoptic nucleus of the hypothalamus, composed of 9 amino acids, and transported to the neurohypophysis at a rate of 2 mm to 3 mm per day freed. The cysteine (Cys) residues at positions "1" and "6" form a 6-peptide ring structure in the form of disulfide bonds.


(1) Effect on mammary glands: The breast during lactation continuously secretes milk under the action of prolactin, which is stored in the acinar glands of the breast. Oxytocin can shrink the myoepithelial-like cells around the breast acinar, and promote the breast milk with the lactating function.

(2) The effect on the uterus: Oxytocin has a strong effect on promoting the contraction of the uterus, but the pregnant uterus is more sensitive. Estrogen can increase the sensitivity of the uterus to oxytocin, while progesterone does the opposite.


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