Linaclotide 851199-59-2

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Product Information

Product name	Linaclotide
CAS No.	851199-59-2
Molecular Formula	C59H79N15O21S6
Molecular Weight	1526.736 g/mol
Quality Standard	98% up, Medicine Grade
Appearance	White powder
Sequence	H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH cyclic(1-6),(2-10),(5-13)-tris(disulfide)

COA of Linaclotide

Test	Specifications
Appearance	White or almost white crystalline powder
Identity by HPLC	The reaction is same with the reference substance
Amino Acid Composition	±20% of theoretical
Purity (HPLC)	≥ 98.0%
Related Substance(By HPLC)	Total Impurities(%)≤ 2.0% Largest Single Impurity(%)≤ 1.0%
Acetate Content(By HPLC)	≤15%
Water Content(By HPLC)	≤5.0%
Bacterial Endotoxins	≤5IU/mg

Usage

Function of Linaclotide

Linaclotide can bind to the guanylate cyclase C-type receptor (GC-C) in the intestinal tract after being taken orally into the human body to increase the intracellular and extracellular cyclic guanylic acid (cGMP) concentration and stimulate the secretion of intestinal juice , To accelerate the migration of the gastrointestinal tract, thereby increasing the frequency of bowel movements. Due to its unique mechanism of action, it is promising to become a therapeutic drug that can not only treat constipation, but also treat abdominal distension, abdominal pain and other clinical symptoms.

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