Nicergoline 27848-84-6

98.5% up by HPLC

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Product Information

Product name	Nicergoline
CAS No.	27848-84-6
Molecular Formula	C24H26BrN3O3
Molecular Weight	484.393
Quality Standard	98.5% up by HPLC, EP
Appearance	White powder

COA of Nicergoline

ITEMS		SPECIFICATION	RESULTS
Appearance		White or buff powder	White powder
Melting point		133ºC--136ºC	135--136ºC
Specific optical rotation		Conforms	Conform
Clarity and color of the solution		Clear	Clear
Related substances		Total impurity ≤1.5%	0.18%
		Nor-nocergoline (B)≤0.50%	0.02%
		Chioronicergoline (A)≤0.5%	0.04%
		MeLUOL (C)≤0.30%	0.02%
		Unidentified impurity:≤0.30%	0.06%
Water		≤0.5%	0.06%
Heavy metal		≤20ppm	Conform
Residue on ignition		≤0.05%	0.02%
Assay		98.5%--102%	99.3%
Residue solvents		Conform	Conform
1	Acetone	≤1000ppm	450ppm
2	Diethyl ether	≤2000ppm	140ppm
3	Ethanol	≤1000ppm	40ppm
4	Methanol	≤1000ppm	90ppm
5	Toluene	≤500ppm	30ppm
6	Dichloromethan	≤100ppm	<50ppm
7	Triethylamine	≤500ppm	230ppm
Conclusion		Conform with EP 5.0

Usage

Nicergoline, a semisynthetic ergot alkaloid derivative, is a potent, selective and orally active α1A-adrenergic receptor antagonist. Nicergoline has a vasodilatory effect. Nicergoline improves cognitive function in Alzheimer's mice.

Function of Nicergoline

1. Improve cerebral circulation: Nicergoline can dilate resistance blood vessels, thereby improving cerebral circulation. As a specific adrenergic α1 receptor blocker, the drug can inhibit the pressor reflex of resistance vessels, increase the local cerebral blood flow and glucose utilization during the reperfusion period after bilateral internal carotid artery ligation in rats; reduce the blood pressure in anesthetized dogs blood pressure, but does not affect the cerebral blood flow of Chemicalbook; and can improve the cerebral vasospasm induced by experimental subarachnoid hemorrhage in rabbits.

2. Improve brain metabolism and electrophysiological activities: Long-term treatment with nicergoline can improve the glucose utilization rate of brain extracts from aged rats. Acute medication can improve memory function in elderly subjects, increase the total energy of EEG topography, and reduce slow waves.