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Nicergoline 27848-84-6

Nicergoline 27848-84-6

98.5% up by HPLC
  • Product Details

Product Information


Product name

Nicergoline

CAS No.

27848-84-6

Molecular Formula

C24H26BrN3O3

Molecular Weight

484.393

Quality Standard

98.5% up by HPLC, EP

Appearance

White powder


COA of Nicergoline


ITEMS 

SPECIFICATION

RESULTS

Appearance 

White or buff powder  

White powder

Melting point 

133ºC--136ºC

135--136ºC

Specific optical rotation

Conforms 

Conform 

Clarity and color of the solution 

Clear 

Clear 

Related substances

Total impurity ≤1.5%

0.18%

Nor-nocergoline (B)≤0.50%

0.02%

Chioronicergoline (A)≤0.5%

0.04%

MeLUOL (C)≤0.30%

0.02%

Unidentified impurity:≤0.30%

0.06%

Water 

≤0.5%

0.06%

Heavy metal 

≤20ppm

Conform 

Residue on ignition 

≤0.05%

0.02%

Assay 

98.5%--102%

99.3%

Residue solvents

Conform 

Conform 

1

Acetone 

≤1000ppm

450ppm

2

Diethyl ether

≤2000ppm

140ppm

3

Ethanol 

≤1000ppm

40ppm

4

Methanol 

≤1000ppm

90ppm

5

Toluene 

≤500ppm

30ppm

6

Dichloromethan 

≤100ppm

<50ppm

7

Triethylamine 

≤500ppm

230ppm

Conclusion 

Conform with EP 5.0


Usage


Nicergoline, a semisynthetic ergot alkaloid derivative, is a potent, selective and orally active α1A-adrenergic receptor antagonist. Nicergoline has a vasodilatory effect. Nicergoline improves cognitive function in Alzheimer's mice.


Function of Nicergoline

1. Improve cerebral circulation: Nicergoline can dilate resistance blood vessels, thereby improving cerebral circulation. As a specific adrenergic α1 receptor blocker, the drug can inhibit the pressor reflex of resistance vessels, increase the local cerebral blood flow and glucose utilization during the reperfusion period after bilateral internal carotid artery ligation in rats; reduce the blood pressure in anesthetized dogs blood pressure, but does not affect the cerebral blood flow of Chemicalbook; and can improve the cerebral vasospasm induced by experimental subarachnoid hemorrhage in rabbits.

2. Improve brain metabolism and electrophysiological activities: Long-term treatment with nicergoline can improve the glucose utilization rate of brain extracts from aged rats. Acute medication can improve memory function in elderly subjects, increase the total energy of EEG topography, and reduce slow waves.

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If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

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