Oseltamivir Phosphate 204255-11-8

99% up by HPLC

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Product Details

Product Information

Product name	Oseltamivir Phosphate
Molecular Formula	C16H28N2O4.H3PO4
Molecular Weight	410.4
CAS No.	204255-11-8
Quality Standard	99% up, medical grade
Appearance	White powder

COA of Oseltamivir Phosphate

Test Item	Specification	Results
Appearance	White to off-white crystalline powder	White crystalline powder
Specific rotation	-30.7^o ~ -32.6^o	-31.4^o
Identification:	IR: Spectrum of the sample corresponds to that of reference standard.	Conform
Identification:	HPLC: The retention time of major peak of test solution should correspond to that of comparison solution.	Conform
Related substances	Impurity I NMT 0.1%	0.01%
	Impurity II NMT 0.1%	ND
	Impurity III NMT 0.1%	0.04%
	Impurity IV NMT 0.1%	0.01%
	Each of unspecified impurity NMT 0.1%	0.05%
	Total impurities NMT 0.5%	0.1%
Related solvents	Acetone NMT 5000ppm	81ppm
	Ethanol NMT 5000ppm	ND
	Dichloromethane NMT 600ppm	ND
	Ethyl acetate NMT 5000ppm	ND
	n-Heptane NMT 5000ppm	ND
	Toluene NMT 890ppm	ND
Water	NMT 0.5%	0.3%
Heavy metals	NMT 10ppm	Conform
Assay	98.0% ~ 101.5% (on anhydrous basis)	99.4%
Conclusion	The product conforms to the above specifications

Usage

Funtion of Oseltamivide phosphate
Oseltamivide phosphate is rapidly metabolized to oseltamivir carboxylate by absorption through the gastrointestinal tract and at least 75% of the oral dose is involved in systemic circulation in the form of oseltamivir carboxylate.

The active ingredient Is a potent and unique neuraminidase inhibitor that acts on all aspects of influenza virus infection andprevents the replication of all clinically relevant strains of influenza A or B viruses. In vitro in very low nanomolar concentrations that have inhibitory effect.
The active metabolite was observed to inhibit the growth of influenza virus in vitro and it was also observed in vivo to inhibit the replication and pathogenicity of influenza virus.

Oseltamivide phosphate reduces the spread of influenza A or B viruses by inhibiting the release of the virus from the infected cells.

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