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OSELTAMIVIR PHOSPHATE 204255-11-8

OSELTAMIVIR PHOSPHATE 204255-11-8

99% up , Pharmaceutical Grade
  • Product Details

 

Product Information

 

Product name

Oseltamivir Phosphate

Molecular Formula

C16H28N2O4.H3PO4

Molecular Weight

410.4

CAS No.

204255-11-8

Quality Standard

99% up, medical grade

Appearance

White powder

 

COA of Oseltamivir Phosphate

 

Test Item

Specification

Results

Appearance

White to off-white crystalline powder

White crystalline powder

Specific rotation

-30.7o ~ -32.6 o

-31.4 o

Identification:

IR: Spectrum of the sample corresponds to that of reference standard.

Conform

HPLC: The retention time of major peak of test solution should correspond to that of comparison solution.

Conform

Related substances

Impurity I NMT 0.1%

0.01%

Impurity II NMT 0.1%

ND

Impurity III NMT 0.1%

0.04%

Impurity IV NMT 0.1%

0.01%

Each of unspecified impurity NMT 0.1%

0.05%

Total impurities NMT 0.5%

0.1%

Related solvents

Acetone NMT 5000ppm

81ppm

Ethanol NMT 5000ppm

ND

Dichloromethane NMT 600ppm

ND

Ethyl acetate NMT 5000ppm

ND

n-Heptane NMT 5000ppm

ND

Toluene NMT 890ppm

ND

Water

NMT 0.5%

0.3%

Heavy metals

NMT 10ppm

Conform

Assay

98.0% ~ 101.5% (on anhydrous basis)

99.4%

Conclusion

The product conforms to the above specifications


Usage

 

Funtion of Oseltamivide phosphate
Oseltamivide phosphate is rapidly metabolized to oseltamivir carboxylate by absorption through the gastrointestinal tract and at least 75% of the oral dose is involved in systemic circulation in the form of oseltamivir carboxylate.

The active ingredient Is a potent and unique neuraminidase inhibitor that acts on all aspects of influenza virus infection andprevents the replication of all clinically relevant strains of influenza A or B viruses. In vitro in very low nanomolar concentrations that have inhibitory effect. 
The active metabolite was observed to inhibit the growth of influenza virus in vitro and it was also observed in vivo to inhibit the replication and pathogenicity of influenza virus. 

Oseltamivide phosphate reduces the spread of influenza A or B viruses by inhibiting the release of the virus from the infected cells.

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