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Nilotinib 641571-10-0

Nilotinib 641571-10-0

99% up by HPLC
  • Product Details

Product Information


Product name

Nilotinib

CAS No.

641571-10-0

Molecular Formula

C28H22F3N7O

Molecular Weight

529.523

Quality Standard

99% up by HPLC

Appearance

White to pale yellow powder


Usage


Function of Nilotinib

Nilotinib is improved from the molecular structure of imatinib, and has stronger selectivity for BCR-ABL kinase activity, and its inhibitory effect on tyrosine kinase is 30 times stronger than that of imatinib, which can inhibit Kinase activity of imatinib-resistant BCR-ABL mutants, while also inhibiting KIT and PDGFR kinase activities. For the treatment of chronic myeloid leukemia (CML), a life-threatening blood cancer that is refractory to or intolerable to imatinib mesylate. Based on a pivotal Phase II clinical study design evaluating the positive results of oral nilotinib in clinical trials against imatinib mesylate or in patients with Ph+ CML in the slow and accelerated phases of apparent toxicity: High efficacy, good tolerance, and manageable safety.

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