Ketotifen hydrogen fumarate 34580-14-8

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Product Information

Product name	Ketotifen hydrogen fumarate
CAS No.	34580-14-8
Molecular Formula	C₂₃H₂₃NO₅S
Molecular Weight	425.505
Quality Standard	98.5% up by HPLC
Appearance	White to brownish-yellow, fine crystalline powder

COA

ANALYSIS	SPECIFICATION	RESULTS
Appearance	White to brownish-yellow, fine crystalline powder	Almost white fine crystalline powder
Identification	The infrared absorption spectrum of the sample is concordant with the reference standard	Conforms
Clarity and colour of solution	The solution is clear and not more intensity coloured than reference solution Y4, BY4 or B4.	Conforms
Loss on drying	≤0.5%	< 0.1%
Sulfated ash	≤0.1%	< 0.1%
Assay(Titration)	≤20ppm	<20ppm
Related substances (by HPLC)	Impurity A ≤ 0.2%	0.06%
	Impurity G ≤ 0.15%	<LOD
	Any unspecified impurity ≤ 0.10%	<LOD
	Total impurities ≤ 0.3%	0.06%
Conclusion	The product complies with R1-CEP 2004-269-Rev 01

Usage

What is Ketotifen fumarate?

Ketotifen hydrogen fumarate is an antihistamine and mast cell stabilizer medication. It's primarily used to manage allergic conditions such as allergic conjunctivitis (itchy, watery eyes due to allergies) and asthma.

Its functions include:

Antihistamine: Ketotifen works by blocking the effects of histamine, a substance produced by the body during an allergic reaction. By inhibiting histamine, it helps alleviate symptoms like itching, redness, and swelling.

Mast Cell Stabilization: It also stabilizes mast cells, which are involved in allergic reactions. Mast cells release histamine and other inflammatory substances when triggered by allergens. Ketotifen helps prevent these cells from releasing these substances, reducing the severity of allergic reactions.

Ketotifen is available in various forms, including eye drops for allergic conjunctivitis and oral preparations for asthma and other systemic allergic conditions. As with any medication, it's essential to use Ketotifen as prescribed by a healthcare professional to achieve the best results and minimize potential side effects.