Nitrofurantoin 67-20-9

98% -102%, EP

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Product Details

Product Information

Product name	Nitrofurantoin
CAS No.	67-20-9
Molecular Formula	C8H6N4O5
Molecular Weight	238.159
Quality Standard	98%-102%
Appearance	A yellow crystalline powder or yellow crystals

COA

ANALYSIS	SPECIFICATION	RESULTS
Appearance	A yellow crystalline powder or yellow crystals	Conforms
Identification	A: The solution should show two absorbance maxima at 266 and 367nm. The ratio of the maximum absorbance at 367nm to that of the maximum absorbance at 266nm should be 1.36 to 1.42.	Conforms
Identification	B: A brown color develops on reaction with specified reagents.	Conforms
Loss on drying	≤1.0%	0.070%
Sulphated Ash	≤0.1% on 1g of sample	0.02%
Related substances (TLC)	≤1.0%	0.06%
Assay (UV)	98% to 102% (calculated on the dried basis)	100.7%
Residual solvent(GC) (In-house)	Methanol ≤ 500ppm	< 58ppm
Residual solvent(GC) (In-house)	Acetone ≤ 500ppm	< 18ppm
Particle size(Malvern Particle Size Analyzer) In-house	D(90) < 100 μm	81 μm
Conclusion	The product complies with above specification.

Usage

What is Nitrofurantoin?

Nitrofurantoin is an antibiotic that is commonly used to treat bacterial infections, specifically those affecting the urinary tract. It belongs to a class of antibiotics known as nitrofurans. Nitrofurantoin is often prescribed for urinary tract infections (UTIs) caused by susceptible bacteria.

The mechanism of action of nitrofurantoin involves interfering with the synthesis of bacterial DNA, RNA, and proteins. It inhibits various enzymes and processes involved in bacterial cell metabolism, ultimately leading to the death of the bacteria.

It is important to note that nitrofurantoin is primarily effective against bacteria that commonly cause urinary tract infections, such as Escherichia coli. It is not typically used for treating infections in other parts of the body due to its limited spectrum of activity.