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γ-aminobutyric acid GABA 56-12-2

γ-aminobutyric acid GABA 56-12-2

99% up
  • Product Details

Product Information


Product name

γ-aminobutyric acid ; Gamma aminobutyric acid ; GABA ; 4-aminobutyricaeid;4-AB

CAS No.

56-12-2

Molecular Formula

C4H9NO2

Molecular Weight

103.1

Quality Standard

99% up, Cosmetic Grade

Appearance

White powder


COA of Nonapeptide-1


TEST

SPECIFICATION

RESULTS

Appearance

White crystalline powder

Conforms

Solution clarification

1g sample is dissolved in 10ml water, solution should be clarified.

Conforms

 Assay (on dry basis)

99.0%

99.35% 

Melting point

196C - 203C

197.5C - 197.9C

Heavy metal

≤ 10 ppm

Conforms

Residue Ignition

≤0.5%

0.36%

Chloride(Q)

≤0.10%

Conforms

Bulk density (loose)

40ppm

Conforms

Tap density

0.4-0.6/cm3

0.45/cm3

pH

0.5-0.7/cm3

0.59/cm3

Microbiology

6.5-7.5

7.31

Total plate count

≤1000cfu/g

500cfu/g                                                                                                                        

Mold

≤100 cfu/g

Conforms

Escherichia Coli

Negative

Conforms

Conclusion

Conforms with specification


Usage


γ-aminobutyric acid (Gamma-aminobutyric acid, GABA) is a non-protein amino acid, which is widely found in vertebrates, plants and microorganisms.


There are currently three production methods for GABA: chemical synthesis, plant enrichment, and biotransformation.

         The reaction conditions of chemical synthesis are relatively severe, and there are chemical residues. Even if the purity is high, it is not a natural product, and is mainly used in the chemical and pharmaceutical fields.

        The plant enrichment method uses the endogenous enzyme transformation of plant tissues to prepare GABA, but the GABA obtained by this method has low purity and is mostly used in the food industry. There are many GABA ingredients made from rice germ or germinated brown rice on the market to produce functional foods with functions of relieving fatigue, assisting in lowering blood pressure, and improving sleep.

        The early research of the biotransformation method used Escherichia coli as the production strain. During the fermentation and culture process, the decarboxylation of glutamate decarboxylase was used to convert L-glutamic acid into GABA, and the pure GABA product was obtained after separation and purification. With the continuous development of biotechnology, some strains that also contain glutamate decarboxylase, such as yeast and lactic acid bacteria, have gradually replaced E. coli, thereby obtaining safer products.


       Our GABA is fermented with our own research and development enzyme, and the purity is able to over 99%.

Function of γ-aminobutyric acid


γ-aminobutyric acid  (GABA) has long been considered to be related to various stress and defense systems of plants. GABA increases as plants are stimulated, and is considered to be an effective mechanism in plants that responds to various external changes, internal stimuli, and ionic environment factors such as pH, temperature, and external natural enemies. GABA can also regulate the internal environment of plants, such as antioxidant, ripening, and preservation of plants. In recent years, GABA has also been found in plants as a signal molecule to transmit expanded information in plants. GABA has been found in soybeans, Arabidopsis, jasmine, strawberries and other plants one after another. Low concentration of GABA helps plant growth and development, while high concentration will have the opposite effect.


 GABA is the most important inhibitory neurotransmitter in the central nervous system of mammals. It participates in a variety of physiological activities in the body. It has anti-anxiety, lowering blood pressure, improving liver and kidney function, accelerating alcohol metabolism, promoting brain vitality, and preventing skin aging. And other functions. GABA plays a particularly prominent role in anti-aging.

1. Delay nerve cell senescence

        GABA can increase the activity of glucose phosphatase, make brain cells active, promote brain tissue metabolism, restore brain cell vitality, and improve nerve function. Researchers from the University of Science and Technology of China, the Kunming Institute of Zoology of the Chinese Academy of Sciences, and the University of Utah in the United States have found that the decrease in the neurotransmitter GABA in the brain may be an important cause of brain aging.

        GABA can help nerve cells to be in a state of high ability to recognize signals. Researchers applied a small amount of GABA to nerve cells in the visual cortex of the brain of the elderly rhesus monkeys. As a result, they found that the behavior of the neurons became "young". Another group of studies on elderly cynomolgus monkeys also got the same result. The visual function of cynomolgus monkeys is similar to that of humans, and will deteriorate with age. When the brain is at its peak, they can select signals to respond. Elderly cynomolgus monkeys lack GABA, which leads to degeneration of nerve cells and decreased visual selection ability. By injecting GABA and GABAA receptor agonists into the body of aging macaques, the visual cortex cells can restore the orientation and direction selectivity of visual stimulation to a greater extent, allowing senescent cells to show young characteristics.

2. Repair skin function

        The expression of glutamate decarboxylase GAD67 can be observed in the skin of humans and mice. GABA catalyzed by GAD can stimulate the synthesis of hyaluronic acid and increase the survival rate of dermal fibroblasts exposed to hydrogen peroxide. GABA can accelerate the healing of back wounds in rats. Compared with epidermal growth factor, treatment with GABA can effectively inhibit inflammation and stimulate epidermal cell regeneration.

3. Soothes wrinkles

       There are three types of receptors recognized and bound by GABA in animals: GABAA, GABAB, and GABAC receptors. The GABAA receptor is a hetero-oligomeric transmembrane glycoprotein composed of five subunits embedded in the double lipid layer of nerve cell membranes. The center of these five subunits is a chloride ion channel. GABA regulates the concentration of chloride ions inside and outside the cell by binding to the GABAA receptor. When GABA binds to the GABAA receptor, the chloride channel on the cell membrane opens. Generally, the intracellular ion concentration is lower than the extracellular ion concentration, and the chloride ion enters the cell along the concentration difference. The increase of chloride ions inside the cells inhibits the excitability of nerve cells, thereby weakening the ability of nerve cells to contract muscle cells, so that the originally over-tensed wrinkle muscles are relaxed and wrinkles can be stretched.


With the increase of age or mental stress, the content of GABA in the human body gradually decreases. When the human body lacks GABA, it is easy to produce negative emotions such as anxiety, restlessness, and worry, the skin will also become dull and lose its elasticity, and wrinkles will appear over time. The use of GABA-containing cosmetics can effectively supplement the missing GABA, relax wrinkle muscles, repair the epidermis, promote the synthesis of HA and collagen in the dermis, and keep the skin young.

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