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Ademetionine 1,4-butanedisulfonate SAM 101020-79-5

Ademetionine 1,4-butanedisulfonate SAM 101020-79-5

99% up by HPLC
  • Product Details

Product Information


Product name

Ademetionine 1,4-butanedisulfonate / SAM / SAMe

CAS No.

101020-79-5

Molecular Formula

C23H41N6O17S5-

Molecular Weight

833.91

Quality Standard

99% up by HPLC

Appearance

White powder


COA of Ademetionine 1,4-butanedisulfonate


ITEMS

STANDARDS

RESULTS

Appearance

A white or almost white powder

White powder

Solubility

Freely soluble in water, practically insoluble in ethanol and in acetone.

Conforms

Identification

1.    The gas it produced can make wet potassium iodate test pater show blue.

Conforms

2.    UV: it has absorption maximum at the 258nm

3.    HPLC: the retention time of the principal peak in the chromatogram obtained with test solution is in accordance with that of the reference.

pH

2.1~2.5

2.4

Clarity and color of solution

Color: ≤Y3# or YG3#

Conforms

A solution should be clear.

Isomers

(S,S-Isomer) ≥70%

74.00%

Related substances

Adenine≤0.4%

0.05%

S-Adenosyl-L-Homocysteine≤0.4%

0.09%

Methylthioadenosine≤2.0%

0.43%

Decarboxylation adenosine methionine≤1.2%

1.00%

The other unknown impurities≤1.0%

0.05%

Total of impurities≤4.0%

1.80%

Water

≤6.0%

2.40%

Residual solvents

Ethyl acetate≤5000ppm

Conforms

Microbial limit tests

Bacteria≤1000cfu/g

Conforms

Bacterial endotoxins

≤0.438 EU/mg

Conforms

Content (dried basis)

Butanedisuphonic acid: 46.0~51.0%

47.20%

Adenosine methionine: 48.0~53.0%

52.20%

Total≥96.0%

99.40%

Conclusion

Conforms to enterprise standard


Usage


Function of Ademetionine 1,4-butanedisulfonate

Ademetionine 1,4-butanedisulfonate (SAM / SAMe) is a physiologically active molecule commonly found in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione, coenzyme A, etc.) (transsulfation) , participates important functions of biochemical reaction in the body.


The multiple mechanisms of adenosylmethionine are mainly reflected in the following aspects:

1. Transmethylation: Improve liver cell membrane fluidity, enhance Na+-K+-ATPase activity, promote bile secretion and operation, and participate in neurotransmitter synthesis, which can improve patient mood.

2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.

3. Transformation of propylamino group: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.


Indication of Ademetionine 1,4-butanedisulfonate:

Suitable for intrahepatic cholestasis before and after cirrhosis.

Suitable for intrahepatic cholestasis during pregnancy.

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