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Telmisartan 144701-48-4

Telmisartan 144701-48-4

99% up by HPLC
  • Product Details

Product Information


Product name

Telmisartan

CAS No.

144701-48-4

Molecular Formula

C33H30N4O2

Molecular Weight

514.62

Quality Standard

99% up, Medicine Grade

Appearance

White Powder


COA of Telmisartan


  TEST

SPECIFICATION

RESULT

Appearance

White Powder

Complies

Related substance (HPLC)

99% min

99.8%

Odor

Characteristic

Complies

Assay

99% min

99.21%

Sieve anaysis

100% pass 80 mesh

Complies

Heavy metal

< 10 ppm

Complies

As

<0.1ppm

0.05ppm

Pb

<0.1ppm

0.05ppm

Cd

<0.1ppm

0.05ppm

Residual Solvents

<100ppm

Complies

Residual Pesticide

Negative

Complies

Total Plate Count

<1000cfu/g

Complies

Yeast&Mold

<100cfu/g

Complies

E. Coli

Negative

Complies

Salmonella

Negative

Complies

Conclusion

Conforms with Enterprise standard


Usage


Non-peptide angiotensin Ⅱ receptor antagonists can selectively and irreversibly block ATI receptors, but have no effect on other receptor systems. For mild to moderate hypertension. Telmisartan is a new antihypertensive drug. It is a specific angiotensin Ⅱ receptor (ATⅠ) antagonist for the treatment of essential hypertension. The alternative angiotensin Ⅱ receptor binds with high affinity to ATⅠ receptor subtype (known angiotensin Ⅱ action site). Telmisartan does not have any agonist effect at the ATⅠ receptor site. It selectively binds to ATⅠ receptor, and the binding effect is long-lasting. It has no affinity for other receptors, including ATII and AT receptors with less characteristics. The function of the other receptors mentioned above is unknown, and the possible receptor over stimulation effect is unknown due to the increase of angiotensin II level caused by Telmisartan. Telmisartan does not inhibit human plasma renin and does not block ion channels. Without inhibiting angiotensin converting enzyme II, the enzyme can also degrade the adverse reactions caused by the enhanced action of bradykinin. Administration of 80 mg telmisartan in human body can almost completely inhibit the increase of blood pressure caused by angiotensin II. The inhibitory effect lasted for 24 hours and could still be measured at 48 hours. The hypotensive effect was gradually obvious within 3 hours after the first dose. The maximum antihypertensive effect can be obtained 4 weeks after the start of treatment and can be maintained in long-term treatment. If the treatment is suddenly interrupted, the blood pressure will gradually return to the pre-treatment level after a few days without rebound hypertension. In the clinical trial of directly comparing the two hypertension drugs, the incidence of dry cough in the treatment group was significantly lower than that in the angiotensin converting enzyme inhibitor treatment group.

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