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Valsartan 137862-53-4

Valsartan 137862-53-4

98% up by HPLC, EP/USP/JP
  • Product Details

Product Information


Product name

Valsartan

CAS No.

137862-53-4

Molecular Formula

C24H29N5O3

Molecular Weight

435.519

Quality Standard

98% up, USP/JP/EP

Appearance

White to almost white powder


COA of Valsartan


ITEMS

STANDARDS

RESULTS

Appearance

White to almost white powder

White powder

Identification

Infrared absorption:

The IR spectrum is consistent with that obtained with the reference

Conforms

The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay

Conforms

Absorbance

NMT 0.02

0.003

Water

NMT2.0%

0.56%

Residue on ignition

NMT0.1%

0.06%

Heavy metals

NMT0.001%

Related compounds

(HPLC)

Compound A NMT1.0%

0.49%

Compound B NMT0.2%

0.08%

Compound C NMT0.1%

Undetected

Any other individual impurity NMT0.1% (excluding compound A )

0.04%

Total impurities NMT0.3% (excluding compound A )

0.20%

Residual solvents(GC)

Ethyl acetate NMT5000ppm

2820ppm

Dichloromethane NMT600ppm

Undetected

Methanol NMT3000ppm

Undetected

N,N-Dimethylformamide NMT880ppm

Undetected

Assay

98.0—102.0%

99.2%

Conclusion

The analysis results show that this batch of valsartan conforms to USP


Usage


Function of Valsartan

Valsartan is an angiotensin II receptor antagonist anti-hypertensive drug. The drug can block the type I (AT1) receptor of angiotensin II, increase the plasma level of angiotensin II and stimulate The unblocked AT2 receptor also counteracts the role of the AT1 receptor, so as to achieve the effect of dilating blood vessels and lowering blood pressure, the effect is lasting and stable, and the toxic and side effects are small. Therefore, valsartan is mainly suitable for antihypertensive, mild to moderate primary hypertension, especially for the treatment of secondary hypertension caused by kidney damage.

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Send A Message
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