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Irbesartan 138402-11-6

Irbesartan 138402-11-6

98% up by HPLC, EP/USP
  • Product Details

Product Information


Product name

Irbesartan

CAS No.

138402-11-6

Molecular Formula

C25H28N6O

Molecular Weight

428.53

Quality Standard

98% up, USP/ EP

Appearance

White to almost white powder


COA of Irbesartan


ITEMS

STANDARDS

RESULTS

Appearance

White to off-white powder

White powder

Identification

Infrared absorption:

The IR spectrum is consistent with that obtained with the reference

Conforms

The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay

Conforms

Water

NMT 0.5%

0.24%

Limit or Azide

NMT10ppm

Not detected

Heavy metals

NMT0.002%

Conforms

Related compounds

(HPLC)

Compound A NMT0.2%

0.01%

Any other impurity NMT0.1%

0.04%

Total impurity NMT0.5%

0.09

Residual solvents(GC)

Ethanol NMT 5000ppm

2307 ppm

Toluene NMT 890ppm

238 ppm

Dichloromethane NMT3000 ppm

Not detected

N,N-Dimethylformamide NMT880 ppm

Not detected

T-butyl Methyl Ether NMT 5000 ppm

Not detected

Assay

98.0—102.0%

99.2%

Conclusion

The analysis results show that this batch of irbesartan conforms to USP


Usage


Function of Irbesartan

Irbesartan is an angiotensin Ⅱ (Angiotensin Ⅱ, Ang Ⅱ) receptor inhibitor, can inhibit the conversion of Ang Ⅰ to Ang Ⅱ, can specifically antagonize the angiotensin converting enzyme 1 receptor (AT1), the antagonism of AT1 is greater than AT28500 Double, by selectively blocking the binding of AngⅡ and AT1 receptors, inhibiting vasoconstriction and the release of aldosterone, resulting in a hypotensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, other hormone receptors, nor does it inhibit ion channels related to blood pressure regulation and sodium balance. It is mainly used for the treatment of essential hypertension and type 2 diabetic nephropathy with hypertension.

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Send A Message
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

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