Ursodeoxycholic acid UDCA 128-13-2

99% up by HPLC

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Product Information

Product name	Ursodeoxycholic acid / UDCA
Synonyms	(4R)-4-[(3R,5S,7S,8R,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;Cholan-24-oic acid, 3,7-dihydroxy-, (3-.alpha.,5-.beta., 7-.beta.)-;Cholan-24-oic acid,3,7-dihydroxy-,(3R,5a,- 7a)-;UDCA;5.beta.-Chol-24-oic acid-3.alpha., 7.beta.-diol;Arsacol;Ursochol;Antigall;Urso (TN);Ursodiol;Antigall (TN);Actigall;Urso;Litursol;Deursil;Desocol;Ursodeoxycholic acid (JP14);Delursan;Ursodiol (USP);deoxy-;Urso Deoxy Cholic Acid;7beta-Hydroxylithocholic acid;Ursodeoxycholoc acid;
CAS No.	128-13-2
Molecular Formula	C₂₄H₄₀O₄
Molecular Weight	392.579
Molecular Structure
Quality Standard	99% up by HPLC
Appearance	White to light yellow powder

COA of Ursodeoxycholic acid / UDCA

Item	Specification	Results
Appearance	A white to light yellow powder	Conforms
Solubility	Insoluble in water, insoluble in methylene chloride, freely soluble in ethanol, soluble in ethanol, slightly soluble in acetone.	Conforms
Identification	IR	Conforms
Melting point	200-204 ^。C	202-204 ^。C
Loss on drying	≤ 1.0%	0.75%
Specific optical rotation	+598.0 ^。- +62.0 ^。	+59.5 ^。
Sulphated Ash	≤ 0.10%	0.06%
Heavy metals	≤ 20 ppm	12 ppm
Burned residue	≤ 0.10%	0.07%
Chloride	≤ 0.10%	0.06%
Related substances (by HPLC)
Chenodeoxycholic acid	≤ 1.00%	0.15%
Lithocholic acid	≤ 0.10%	0.01%
Single impurity	≤ 0.10%	0.05%
Total impurities	≤ 0.15%	0.45%
Residual solvent
Isopropanol	≤ 0.50%	None
Methanol	≤ 0.30%	0.14%
Acetone	≤ 0.50%	0.12%
Ethyl acetate	≤ 0.50%	0.06%

Assay	99% - 102%	99.52%
Conclusion	The sample conforms to standard

Usage

Function and efficacy of Ursodeoxycholic acid / UDCA:

1. Increase the secretion of bile acids, leading to changes in the composition of bile acids, increasing their content in bile, and having a choleretic effect. The average bile acid secretion increased from 1.8 mmol per hour to 2.24 mmol per hour, and long-term use can increase the content of UDCA in bile without increasing the content of bile acid.

2. It can inhibit the synthesis of cholesterol in the liver, significantly reduce the amount of cholesterol and cholesterol esters in bile and the saturation index of cholesterol, which is conducive to the gradual dissolution of cholesterol in stones. In addition, UDCA promotes the formation of liquid cholesterol crystal complexes that accelerate excretion and clearance of cholesterol from the gallbladder to the gut.

3. Relax Audi (Oddi) sphincter, choleretic effect.

4. Reduce liver fat, increase the activity of catalase in the liver, promote the accumulation of liver glycogen, and improve the anti-toxin and detoxification ability of the liver.

5. Can reduce the concentration of triacylglycerol in liver and serum.

6. Inhibit the secretion of digestive enzymes and digestive juices.

7. Foreign studies have also shown that ursodeoxycholic acid has an immunomodulatory effect in chronic liver diseases, and can significantly reduce the expression of HLAI antigens in liver cells and reduce the number of activated T cells. Ursodeoxycholic acid is better than chenodeoxycholic acid (CDCA) in dissolving cholesterol stones in the body

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