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Lenalidomide 191732-72-6 Lenalidomide 191732-72-6

Lenalidomide 191732-72-6
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Basic of Lenalidomide 191732-72-6

  • CAS No.: 191732-72-6
  • Molecular formula:C13H13N3O3
  • Molecular Weight:259.261
  • Standard: USP/BP
  • Appearance: White Crystal Powder

Uses of Lenalidomide 191732-72-6

  • Multiple myeloma treatment

COA of Lenalidomide 191732-72-6


Test Items


Specification


Results


Description


White to off white crystalline powder


Comply


Melting point


166-170°C


167.3-168.1°C


Identification


Positive reaction


Positive reaction


Related substances


≤1.0%


0.16%


Loss on drying


≤0.5%


0.06%


Residue on ignition


≤0.1%


0.02%


Chloride


≤0.014%


<0.014


Heavy Metals


≤20ppm


<20ppm


Clarity of solution


Conform to standard


Complies


Microbial Limit


≤20ppm


<20ppm


Assay


≥99.0%


99.12%


Lenalidomide mechanism of action

At present, there are many main aspects about the anti-cancer effect of the lenalidomide. Respectively, they are: inhibiting the formation of tumor nourishing blood vessels, stimulating the activation of T lymphocytes, the direct anti-tumor effect. Existing studies have shown that the monocytes in human bodies can be produced in inflammatory environment (local tissues can be caused to keep in inflammatory environment in each stage when the tumor is producing).

As for the immunomodulatory drugs such as lenalidomide, one of the important function is that it can inhibit monocytes to produce TNF-α. When TNF-α is reduced, it will be very difficult for the tumor to produce new blood vessels. Moreover, with less blood vessels producing, not only the tumor will be "starved" because of "malnutrition", but also the tumor cells will be very hard to transfer to other human parts through blood. So, it may be said "kill two birds with one stone". Except the action target TNF-α, lenalidomide can also reduce one kind of active substance named COX-2 which can stimulate blood vessels around the tumor to produce. There are many COX-2 in some tumor cells. In addition, with the deepening of the research, the researchers also found that lenalidomide can inhibit VEGF and IL – 6 which can stimulate blood vessels around the tumor to produce.

As for the immunomodulatory drugs such as lenalidomide, one of the important function is that it can inhibit monocytes to produce TNF-α. When TNF-α is reduced, it will be very difficult for the tumor to produce new blood vessels. Moreover, with less blood vessels producing, not only the tumor will be "starved" because of "malnutrition", but also the tumor cells will be very hard to transfer to other human parts through blood. So, it may be said "kill two birds with one stone". Except the action target TNF-α, lenalidomide can also reduce one kind of active substance named COX-2 which can stimulate blood vessels around the tumor to produce. There are many COX-2 in some tumor cells. In addition, with the deepening of the research, the researchers also found that lenalidomide can inhibit VEGF and IL – 6 which can stimulate blood vessels around the tumor to produce.

Why buy lenalidomide 191732-72-6 from Sinoway lenalidomide Manufacturer?

  • Founded in 1987 in Xiamen, Sinoway lenalidomide Manufacturer has 30-year experiences of producing high-quality lenalidomide power.
  • Fast delivery time
  • Easy payment way
  • Low cost lenalidomide 191732-72-6

MORE_DETAIL Lenalidomide 191732-72-6

Basic of Lenalidomide 191732-72-6

  • CAS No.: 191732-72-6
  • Molecular formula:C13H13N3O3
  • Molecular Weight:259.261
  • Standard: USP/BP
  • Appearance: White Crystal Powder

Uses of Lenalidomide 191732-72-6

  • Multiple myeloma treatment

COA of Lenalidomide 191732-72-6


Test Items


Specification


Results


Description


White to off white crystalline powder


Comply


Melting point


166-170°C


167.3-168.1°C


Identification


Positive reaction


Positive reaction


Related substances


≤1.0%


0.16%


Loss on drying


≤0.5%


0.06%


Residue on ignition


≤0.1%


0.02%


Chloride


≤0.014%


<0.014


Heavy Metals


≤20ppm


<20ppm


Clarity of solution


Conform to standard


Complies


Microbial Limit


≤20ppm


<20ppm


Assay


≥99.0%


99.12%


Lenalidomide mechanism of action

At present, there are many main aspects about the anti-cancer effect of the lenalidomide. Respectively, they are: inhibiting the formation of tumor nourishing blood vessels, stimulating the activation of T lymphocytes, the direct anti-tumor effect. Existing studies have shown that the monocytes in human bodies can be produced in inflammatory environment (local tissues can be caused to keep in inflammatory environment in each stage when the tumor is producing).

As for the immunomodulatory drugs such as lenalidomide, one of the important function is that it can inhibit monocytes to produce TNF-α. When TNF-α is reduced, it will be very difficult for the tumor to produce new blood vessels. Moreover, with less blood vessels producing, not only the tumor will be "starved" because of "malnutrition", but also the tumor cells will be very hard to transfer to other human parts through blood. So, it may be said "kill two birds with one stone". Except the action target TNF-α, lenalidomide can also reduce one kind of active substance named COX-2 which can stimulate blood vessels around the tumor to produce. There are many COX-2 in some tumor cells. In addition, with the deepening of the research, the researchers also found that lenalidomide can inhibit VEGF and IL – 6 which can stimulate blood vessels around the tumor to produce.

As for the immunomodulatory drugs such as lenalidomide, one of the important function is that it can inhibit monocytes to produce TNF-α. When TNF-α is reduced, it will be very difficult for the tumor to produce new blood vessels. Moreover, with less blood vessels producing, not only the tumor will be "starved" because of "malnutrition", but also the tumor cells will be very hard to transfer to other human parts through blood. So, it may be said "kill two birds with one stone". Except the action target TNF-α, lenalidomide can also reduce one kind of active substance named COX-2 which can stimulate blood vessels around the tumor to produce. There are many COX-2 in some tumor cells. In addition, with the deepening of the research, the researchers also found that lenalidomide can inhibit VEGF and IL – 6 which can stimulate blood vessels around the tumor to produce.

Why buy lenalidomide 191732-72-6 from Sinoway lenalidomide Manufacturer?

  • Founded in 1987 in Xiamen, Sinoway lenalidomide Manufacturer has 30-year experiences of producing high-quality lenalidomide power.
  • Fast delivery time
  • Easy payment way
  • Low cost lenalidomide 191732-72-6
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