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Griseofulvin 126-07-8 Griseofulvin 126-07-8

Griseofulvin 126-07-8
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Basic information of Griseofulvin

Name

Griseofulvin

Alias

Grisovin;7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione

CAS NO.

126-07-8

Molecular Formula

C17H19ClO6

Molecular Weight

354.7822

Quality Standard

USP/BP/EP

Grade Standard

Medicine grade  / 99% min

Package Size

25kg/drum

Use of Griseofulvin

Griseofulvin is used to treat skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails.

COA of Griseofulvin

Test items

Specifications (BP2011 /EP7.0)

Description

A white or yellow white microfine powder

Identification

A: IR

B:Colour test (a white-red colour develops)

Acidity

Not more than 1.0ml of 0.02M sodium hydroxide is required.

Solubility

Practically insoluble in water,freely soluble in dimethyl formamide and
in tetrachloroethane,slightly soluble in ethanol and in methanol.

Specific optical rotation

Calculated with reference to the dried substance +354°~+364°

Particle size

95% no more than 5um(larger particles which may occasionally exceed 30um)

Melting point

It melts at about 220°C

Appearance of solution

The solution is clear

Not more intensely coloured than reference solution Y4

Related substances:


Dechologriseofulvin

Less than 0.60

Dehydrogriseofulvin

Less than 0.15

Substances soluble in light petroleum

NMT 0.20%

Loss on drying

NMT 1.00%

Sulphated ash

NMT 0.20%

Abnormal toxicity

Five mice orals,none of the mice dies within 48h

Assay(anhydrous substance)

97.0% to 102.0%



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MORE_DETAIL Griseofulvin 126-07-8

Basic information of Griseofulvin

Name

Griseofulvin

Alias

Grisovin;7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione

CAS NO.

126-07-8

Molecular Formula

C17H19ClO6

Molecular Weight

354.7822

Quality Standard

USP/BP/EP

Grade Standard

Medicine grade  / 99% min

Package Size

25kg/drum

Use of Griseofulvin

Griseofulvin is used to treat skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails.

COA of Griseofulvin

Test items

Specifications (BP2011 /EP7.0)

Description

A white or yellow white microfine powder

Identification

A: IR

B:Colour test (a white-red colour develops)

Acidity

Not more than 1.0ml of 0.02M sodium hydroxide is required.

Solubility

Practically insoluble in water,freely soluble in dimethyl formamide and
in tetrachloroethane,slightly soluble in ethanol and in methanol.

Specific optical rotation

Calculated with reference to the dried substance +354°~+364°

Particle size

95% no more than 5um(larger particles which may occasionally exceed 30um)

Melting point

It melts at about 220°C

Appearance of solution

The solution is clear

Not more intensely coloured than reference solution Y4

Related substances:


Dechologriseofulvin

Less than 0.60

Dehydrogriseofulvin

Less than 0.15

Substances soluble in light petroleum

NMT 0.20%

Loss on drying

NMT 1.00%

Sulphated ash

NMT 0.20%

Abnormal toxicity

Five mice orals,none of the mice dies within 48h

Assay(anhydrous substance)

97.0% to 102.0%


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