English
banner
Products
Home

API

GEMCITABINE HYDROCHLORIDE 122111-03-9

GEMCITABINE HYDROCHLORIDE 122111-03-9

EP / USP
  • Product Details

Product Information


Product name

Gemcitabine hydrochloride

Molecular Formula

C9H12ClF2N3O4

Molecular Weight

299.66

CAS No.

122111-03-9

Quality Standard

EP / USP, medical grade

Appearance

White powder


COA of Gemcitabine Hydrochloride


Test

Specification

Result

Characters

White or almost white powder

Conform

Identification

The IR spectrum of sample is concordant with the IR spectrum of Gemcitabine hydrochloride reference standard.

Conform

Chloride

Conform

Solubility

Soluble in water; sparingly soluble in methanol, practically insoluble in alchohol and in polar organic solvents

Conform

pH

2.0 to 3.0

2.2

Specific rotation

+43° to +50°

+49°

Heavy metals

Not more than 10ppm

<10ppm

Residue on ignition

Not more than 0.1%

0.06%

Related substances

Cytosine: not more than 0.1%

0.02%

α-anomer: not more than 0.1%

Not detected

Any other impurity: not more than 0.1%

0.04%

Total impurities: not more than 0.2%

0.10%

Bacterial endotoxins

Not more than 0.05 EU/mg

<0.05 EU/mg

bacteria

Not more than 100 CUFU/g

<10 CFU/g

Yeasts & Moulds

Not more than 20 CFU/g

<10 CFU/g

Escherichia coli

Not detected

Not detected

Residual solvents

Methanol: not more than 0.3%

0.0001%

Acetone: not more than 0.5%

0.16%

Isopropyl alcohol: not more than 0.5%

Not detected

Ethylene Dichloride: not more than 5ppm

Not detected

Assay

97.5% to 101.5% ( on as-is basis)

99.4%

Conclusion

Conforms to USP34.



Usage


Function of Gemcitabine hydrochloride

As a prodrug, gemcitabine hydrochloride is a good substrate for phosphorylation of deoxythymidine kinase in the cell and is converted into the following metabolites under the action of enzymes: gemcitabine monophosphate (dFdCMP), gemcitabine diphosphate (dFdCDP) and gemcitabine Phosphate (dFdCTP) dFdCDP and dFdCTP are active products. dFdCDP inhibits ribonucleotide reductase, thereby reducing the amount of deoxynucleotides required for repair of DNA synthesis (especially dCTP). Low levels of dCTP reverse the normal negative feedback inhibition of deoxyglycoside kinase, resulting in more dFdCTP Accumulation. At the same time, dFdCDP inhibits the deamination effect of dCTP-induced deoxycytidine on dFdCMP, and dFdCTP directly inhibits deoxycytidine deaminase, thereby converting more dFdCMP into the active metabolite dFdCMP deamination, and dFdCTP directly inhibits deoxygenation Cytidine deaminase, which converts more dFdCMP into the active metabolite dFdCDP, dFd-CTP and dFdCTP competes with dCTP for binding into the DNA strand, inserting it into the deoxycytidine site in the DNA strand, and allowing guanosine to interact with it After pairing, the gemcitabine molecule is "masked" by this guanosine to prevent it from being removed and repaired by exonuclease, and then DNA strand synthesis stops, and DNA breaks and the cell dies.

Send A Message

If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.
Related Products

MUPIROCIN
MUPIROCIN 12650-69-0
99% up / GMP
IMATINIB MESYLATE
IMATINIB MESYLATE 220127-57-1
In-house Standard
CEFTIOFUR SODIUM
CEFTIOFUR SODIUM 104010-37-9
In-house Specification
OSELTAMIVIR PHOSPHATE
OSELTAMIVIR PHOSPHATE 204255-11-8
99% up , Pharmaceutical Grade
THYMOPENTIN
THYMOPENTIN 69558-55-0
99% up Medical Grade
LOSARTAN POTASSIUM
LOSARTAN POTASSIUM 124750-99-8
98.5% up, USP32 
AZILSARTAN
AZILSARTAN 147403-03-0
99% up, JP/ GMP / PMDA / DMF
CARMUSTINE
CARMUSTINE 154-93-8
96.0% - 102.0% 
Send A Message
Send A Message
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

Home

Products

about

Contact