What Are Broad-spectrum Antifungal Drugs?-www.china-sinoway.com

What are broad-spectrum antifungal drugs?

Mar 16, 2022

Azole antifungals are synthetic broad-spectrum antifungals, including: imidazoles and triazoles. Imidazoles include ketoconazole, miconazole, econazole, clotrimazole, etc. These drugs are currently used as topical drugs for the treatment of superficial fungal infections and skin and mucous membrane Candida infections due to their high oral toxicity. Triazoles, including itraconazole, fluconazole, etc., can be used as the first choice for the treatment of deep fungal infections. In recent years, with fluconazole and itraconazole as the leading compounds, tens of thousands of new triazole compounds have been synthesized, and a number of broad-spectrum, high-efficiency and low-toxic drugs have been screened out, such as Voriconazole, Posaconazole and Ravuconazole, which are considered as the second-generation triazole antifungal drugs, overcome the problems of narrow antibacterial spectrum, low bioavailability, drug interaction and drug resistance of the first-generation drugs, and are the most developed antifungal drugs at present.

Tags : posaconazole antifungal voriconazole

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What are broad-spectrum antifungal drugs?

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