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Good partner for moisturizing - γ polyglutamic acid & Hyaluronate Acid

Good partner for moisturizing - γ polyglutamic acid & Hyaluronate Acid

Jul 16, 2021
Poly-γ-Glutamic Acid ( γ polyglutamic acidγ-PGA , CAS No.: 25513-46-6) is a moisturizer extracted from natto. It has good water solubility, strong water retention, smooth but not greasy skin feel, and is a "good partner" for hyaluronic acid.

The side chain group of polyglutamic acid has strong hydration ability and can absorb moisture in the air; and PGA can form a silky protective film on the skin surface, effectively preventing the evaporation of moisture on the skin surface. The TEWL experiment confirmed that PGA has a long-term moisturizing effect: the 28-day experimental results in the figure below show that PGA can prevent the loss of moisture in the skin for a long time, and the long-term moisturizing effect is better than hyaluronic acid and collagen.

γ-PGA polyglutamic acid enters skin cells, it can induce the production of natural moisturizing factor NMF. And it can maintain the water content between keratinocytes by adjusting and storing water, so that the skin naturally presents a moisturized state. Polyglutamic acid is currently the only functional ingredient known to induce self-increase of natural moisturizing factor (NMF).

Hyaluronic acid (HA) is a component of human skin structure, which can keep the skin moisturized and elastic. However, due to the hyaluronidase contained in the skin, HA degrades rapidly. PGA can inhibit the activity of hyaluronidase in the skin, improve the stability of hyaluronic acid in the skin, and increase the content of hyaluronic acid. Therefore, the combination of polyglutamic acid and hyaluronic acid can synergistically increase the effect and effectively reduce the stickiness of hyaluronic acid.


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