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Alogliptin benzoate 850649-62-6

Alogliptin benzoate 850649-62-6

99% up by HPLC, PMDA/DMF
  • Product Details

Product name

Alogliptin benzoate

CAS No.

850649-62-6

Molecular Formula

C18H21N5O2.C7H6O2

Molecular Weight

461.52

Quality Standard

98% up by HPLC

Appearance

White powder


COA of Alogliptin benzoate


ITEMS

SPECIFICATION

RESULT

Appearance

White or off-white crystalline powder

Complies

Melting point

181.0°C ~185.0°C

182-184°C, melting and decomposition

Specific rotation

+13° ~ +18°

+14.6°

Identification

1. UV: maximum absorption at the wavelength of 278+2nm

Complies

2. IR: be consistent with standard

Complies

3. HPLC the retention time of the main peak of the solution should be consistent with the retention time of the main peak of the reference solution.

Complies

Water

0.5%

0.15%

Residue on ignition

0.2%

0.09%

Heavy metals

20 ppm

Complies

Enantiomer

0.5%

ND

Residual solvents

Ethanol 5000ppm

985 ppm

DMF 880 ppm

ND

DCM 600 ppm

ND

TOL 890 ppm

ND

IPA 5000 ppm

ND

Related

substances

Single impurity 0.1%

0.01%

Total impurities 2.0%

0.05%

Assay

98.0% - 102.0%

100.01%

Conclusion

The sample complies with the above specification


Usage


Alogliptin benzoate is a selective inhibitor of dipeptidyl peptidase-4 (DPP-4). Eating stimulates the small intestine to secrete elevated concentrations of incretins, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), into the bloodstream. These hormones cause islet beta cells to release insulin in a glucose-dependent manner, but these hormones are inactivated by the DPP-4 enzyme within minutes. Inhibition of DPP-4 activity by alogliptin slows the inactivation of these incretins, thereby increasing blood concentrations of these hormones and reducing fasting and postprandial blood glucose in a glucose-dependent manner in patients with type II diabetes.

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Send A Message
Send A Message
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

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