3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 1143-70-0

3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one is produced by the gut flora and is a natural metabolite of ellagitannins, a class of compounds found in pomegranates and some other fruits and nuts.

How does 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one work?

3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one (UA) exerts its biological effects primarily through the following mechanisms, supported by recent research:

‌1. Activation of Mitophagy‌

UA enhances mitochondrial health by promoting ‌mitophagy‌ (the selective degradation of damaged mitochondria) via two key pathways:

• ‌PINK1/Parkin-dependent pathway‌: UA recruits Parkin to ubiquitinate damaged mitochondria, which are then recognized by p62 and engulfed by autophagosomes for lysosomal degradation.
• ‌Parkin-independent pathway‌: UA upregulates ‌BNIP3‌ and ‌NIX‌, proteins that directly bind LC3 to initiate mitophagy without Parkin involvement‌.

‌2. Modulation of Cellular Circadian Rhythms‌

UA regulates ‌clock genes‌ (e.g., Bmal1) to restore disrupted circadian rhythms, particularly in aging cells. It improves sleep quality and mitigates "social jet lag" by stabilizing intestinal barrier function and reducing inflammation-induced rhythm disruption‌.

‌3. Antioxidant and Anti-inflammatory Effects‌

UA scavenges free radicals and suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-17A), reducing oxidative stress and chronic inflammation‌.

‌4. Enhancement of Mitochondrial Function‌

By clearing defective mitochondria, UA stimulates biogenesis of new, functional mitochondria, improving energy metabolism in aging tissues‌.

‌Key Implications‌

These mechanisms underlie UA’s potential in ‌anti-aging, immune modulation, and metabolic health‌, with clinical evidence supporting its safety and efficacy‌.

For further details, refer to Nature and Cell journals, where UA’s mechanisms are extensively documented.