Scientists at the University of Washington Medical School recently discovered that supplementing healthy mice with a natural compound called nicotinamide mononucleotide (NMN)
can offset loss of productivity and reduce typical aging symptoms. Relevant research results were published in the Journal Cell Metabolism.
Scientists have long suspected that weakening the stability of the body's energy supply chain is the key to driving the aging process. The level of nicotinamide adenine dinucleotide (NAD), a key component in energy metabolism, decreases with age. Previous studies have shown that NAD levels in various tissues of aging mice decrease. However, studies have shown that direct administration of NAD to mice does not effectively alleviate aging. Therefore, researchers have identified NMN, a compound upstream of the NAD supply chain. Nicotinamide mononucleotides exist in a variety of natural foods, including broccoli, cabbage and so on. New research shows that NMN absorbs very quickly. NMN was detected in the blood of mice within 3 minutes after they ingested drinking water containing dissolved NMN. In many tissues, NMN in blood is rapidly converted to NAD.
To determine the long-term effects of NMN，the researchers gave one group of mice high doses of NMN drinking water, and the other group received low doses of NMN drinking water, and the third group drank normal water as a control. The results showed that supplementation of NMN had many beneficial effects on the body, including skeletal muscle, liver function and bone mineral density. But these benefits were only significant in older mice. There was no significant effect on young mice, probably because young mice could produce enough NMN themselves. Researchers believe that increased inflammation associated with aging may impair the body's ability to produce NMN, which in turn leads to a decrease in NAD.