In 2018, Herbalmax, an American biotechnology company, released Reinvigorator, a dietary supplement product based on the research results of Harvard Medical College. The main component of Reinvigorator, nicotinamide mononucleotide (NMN)
, has been proved by experiments at the Glenn Center for Aging Biology, Harvard University, that it can prolong the life span of mammals by more than 30%. For this reason, David Sinclair, professor of Harvard Medical College and director of Paul F. Glenn Center for Biological Aging Biology, the main discoverer of the anti-aging effect of NMN, was also named "the 100 most influential people in the world" by Time magazine.
It was not until Herbalmax succeeded in reducing the price of nicotinamide mononucleotides by more than 90% in 2018 through enzymatic technology that the cost of taking nicotinamide mononucleotides NMN entered the affordable range of general high-income groups.
Data show that in recent years, academia has reached a general consensus on the mechanism of aging: the fundamental reason for aging is that DNA damage in cells accumulates with age, leading to the loss of cell function and regeneration ability. NMN can reverse aging by significantly improving the repair ability of DNA damage in cells. According to British media Daily Mail, a study published in Science in March 2017 confirmed that NMN has successfully improved the ability of old mice to repair DNA damage: "After only a week of treatment, the cells of old mice have become indistinguishable from those of young mice." In addition, an experiment published in Cell a year later by Sinclair's team at Harvard University confirmed that NMN significantly reversed the aging of cardiovascular and cerebrovascular system and motor function in mammals caused by aging, making the physical strength of older mammals more than 1.6 times that of their peers.
In the past five years, authoritative research institutes, including the National Institutes of Health and the Federal Center for Aging Research, have carried out research on NMN. Scientists have found that, unlike substances that only improve the youthful state of the face, NMN therapy can quickly restore the whole body functions of mammals, such as cardiovascular, cerebrovascular, muscle tissue and physical fitness. According to media reports, David Sinclair himself started taking NMN very early, and his blood tests showed that many age indicators, including blood sugar, testosterone, hsCRP (hypersensitive C-reactive protein), ALT (alanine aminotransferase), had returned to a younger age.