What exactly is NMN? Nicotinamide mononucleotide (NMN)
precursor of NAD +, a cofactor of longevity protein in human body. So before we
know about NMN, we need to know about NAD +.
NAD + is also known as coenzyme I,
nicotinamide adenine dinucleotide, nicotinamide diphosphate, which is involved
in thousands of reactions in every cell. NAD + is an important coenzyme in the
tricarboxylic acid cycle, which promotes the metabolism of sugar, fat and amino
acids and participates in the synthesis of energy. NAD + is also the sole
substrate of coenzyme I depleting enzyme (the sole substrate of DNA repair
enzyme PARP, the sole substrate of longevity protein Sirtuins, and the sole
substrate of cyclic ADP ribosynthetase CD38/157).
NAD + is a key coenzyme involved in all
aspects of human metabolism. Without NAD +, metabolism will not work. Old
people lack NAD +, so all kinds of big and small problems come. By
supplementing NAD +, they can resist aging in an all-round way.
Therefore, NAD + is very important to human
body and plays an important role in anti-aging. However, with the increase of
age, the level of NAD + in human body is gradually decreasing, leading to the
decrease of mitochondrial activity, accelerating the aging of mitochondria,
cells and even the whole body, and gradually entering a vicious circle, which
may be the reason for our aging.
From the point of view of NAD +
supplementation, the four precursors that can supplement the three metabolic
cycles of NAD + are nicotinic acid, tryptophan, nicotinamide and NMN/NR.
Compared with other NAD + supplementation methods, NMN bypasses the bottleneck
of NAMPT rate-limiting enzymes and can rapidly replenish NAD + in vivo, which
is the best way to replenish NAD +.
NAD + molecules are relatively large, and
it is difficult for NAD + directly supplemented from outside to penetrate the
cell membrane and enter the cell interior, but NMN molecules can easily
penetrate the cell membrane and enter the cell interior. Once inside the cell,
two NMN molecules bind together to form a NAD + molecule.
Therefore, regular intake of this substance
can effectively increase its content in the body, thus helping human beings
repair DNA damage and delay aging!