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Does the "Edicine of Agelessness" Really Exist? Take You to Know the Magic Substance NMN Does the "Edicine of Agelessness" Really Exist? Take You to Know the Magic Substance NMN

What exactly is NMN? Nicotinamide mononucleotide (NMN) is the precursor of NAD +, a cofactor of longevity protein in human body. So before we know about NMN, we need to know about NAD +. NAD + is also known as coenzyme I, nicotinamide adenine dinucleotide, nicotinamide diphosphate, which is involved in thousands of reactions in every cell. NAD + is an important coenzyme in the tricarboxylic acid cycle, which promotes the metabolism of sugar, fat and amino acids and participates in the synthesis of energy. NAD + is also the sole substrate of coenzyme I depleting enzyme (the sole substrate of DNA repair enzyme PARP, the sole substrate of longevity protein Sirtuins, and the sole substrate of cyclic ADP ribosynthetase CD38/157). NAD + is a key coenzyme involved in all aspects of human metabolism. Without NAD +, metabolism will not work. Old people lack NAD +, so all kinds of big and small problems come. By supplementing NAD +, they can resist aging in an all-round way. Therefore, NAD + is very important to human body and plays an important role in anti-aging. However, with the increase of age, the level of NAD + in human body is gradually decreasing, leading to the decrease of mitochondrial activity, accelerating the aging of mitochondria, cells and even the whole body, and gradually entering a vicious circle, which may be the reason for our aging. From the point of view of NAD + supplementation, the four precursors that can supplement the three metabolic cycles of NAD + are nicotinic acid, tryptophan, nicotinamide and NMN/NR. Compared with other NAD + supplementation methods, NMN bypasses the bottleneck of NAMPT rate-limiting enzymes and can rapidly replenish NAD + in vivo, which is the best way to replenish NAD +. NAD + molecules are relatively large, and it is difficult for NAD + directly supplemented from outside to penetrate the cell membrane and enter the cell interior, but NMN molecules can easily penetrate the cell membrane and enter the cell interior. Once inside the cell, two NMN molecules bind together to form a NAD + molecule. Therefore, regular intake of this substance can effectively increase its content in the body, thus helping human beings repair DNA damage and delay aging!
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