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Tacrolimus FK-506 104987-11-3

Tacrolimus FK-506 104987-11-3

98% up by HPLC
  • Product Details

Product Information


Product name

Tacrolimus ; FK-506

CAS No.

104987-11-3

Molecular Formula

C44H69NO12

Molecular Weight

804.02

Quality Standard

98% up by HPLC

Appearance

White or light yellow powder


COA of Tacrolimus


  Items

Specifications

Results

Appearance

White or light yellow powder

White or light yellow powder

Assay

98%-102%

99.1%

Water

3.0%

2.5%

Related substances

Ascomycin 0.8%

0.05%

Dihydrotacrolimus 0.6%

0.3%

Total Impurities 1.5%

0.43%

Residual solvents

Acetone 2000ppm

ND

Ethanol 2000ppm

ND

Heavy metals

20ppm

< 20ppm

Single impurity

0.6%

0.2805%

Total impurity

1.5%

0.33%

Conclusion

Meet the specifications


Usage


Function of Tacrolimus


Tacrolimus (FK506), a macrolide, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase (calcineurin phosphatase), thereby inhibiting T lymphocyte signal transduction and IL-2 transcription, with strong Immunosuppressive properties. In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.

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Send A Message
Send A Message
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

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