Tacrolimus FK-506 104987-11-3

98% up by HPLC

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Product Details

Product Information

Product name	Tacrolimus ; FK-506
CAS No.	104987-11-3
Molecular Formula	C44H69NO12
Molecular Weight	804.02
Quality Standard	98% up by HPLC
Appearance	White or light yellow powder

COA of Tacrolimus

Items	Specifications	Results
Appearance	White or light yellow powder	White or light yellow powder
Assay	98%-102%	99.1%
Water	≤ 3.0%	2.5%
Related substances	Ascomycin ≤ 0.8%	0.05%
	Dihydrotacrolimus ≤ 0.6%	0.3%
	Total Impurities ≤ 1.5%	0.43%
Residual solvents	Acetone ≤ 2000ppm	ND
Residual solvents	Ethanol ≤ 2000ppm	ND
Heavy metals	≤ 20ppm	< 20ppm
Single impurity	≤ 0.6%	0.2805%
Total impurity	≤ 1.5%	0.33%
Conclusion	Meet the specifications

Usage

Function of Tacrolimus

Tacrolimus (FK506), a macrolide, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase (calcineurin phosphatase), thereby inhibiting T lymphocyte signal transduction and IL-2 transcription, with strong Immunosuppressive properties. In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.