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Rabeprazole Sodium 117976-90-6

Rabeprazole Sodium 117976-90-6

97% up by HPLC, EP/GMP/DMF
  • Product Details

Product Information


Product name

Rabeprazole Sodium

CAS No.

117976-90-6

Molecular Formula

C18H20N3NaO3S

Molecular Weight

381.4245

Quality Standard

97% up by HPLC, EP8/GMP/DMF

Appearance

White powder


COA of Rabeprazole Sodium


ITEMS

STANDARDS

RESULTS

Appearance

White or slightly yellowish-white hygoscopic powder

Slightly yellowish-white hygoscopic powder

Solubility

Very soluble to freely soluble in water, and freely soluble in anhydrous ethanol, practically insoluble in heptane.

Complies

Identification

Infrared absorption spectrum is identical to that of rebeprazole sodium reference standard.

Complies

It gives reaction (a) of sodium

Complies

pH

9.5-11.5

10.5

Related substances

(HPLC)

Impurity A: NMT 0.8%

0.05%

Unspecified impurities: NMT 0.10%

0.09%

Total impurities: NMT 1.0%

0.28%

Related substances

(GC)

Methylene chloride: NMT 600ppm

<LOD(LOD=62ppm)

Ethanol: NMT5000ppm

<LOD(LOD=62ppm)

Isopropyl ether: NMT5000ppm

10ppm

Acetone: NMT5000ppm

26ppm

Assay

97.0%-102.0%, calculated on the dried basis

100.6%

Microbial limit

Total aerobic microbial count 1000cfu/g

< 10cfu/g

Total combined yeasts and molds count 100cfu/g

< 10cfu/g

Escherichia coli: absence in 1g

Complies

Conclusion

Complies with the requirements of EP8.7


Usage


Function of Rabeprazole Sodium

Rabeprazole is a treatment drug for digestive tract diseases. Its main function is to inhibit the secretion of gastric acid. It is a proton pump inhibitor. This drug has an inhibitory effect on basic gastric acid and the secretion of gastric acid caused by stimulation. It can inhibit the secretion of gastric acid and can also resist Helicobacter pylori. In addition, this drug has no antagonistic effect on choline receptors and histamine receptors. Clinically, rabeprazole is mainly suitable for gastrointestinal diseases such as peptic ulcer and reflux esophagitis.

This drug is relatively safe when used, and there are generally no obvious serious adverse reactions. Patients occasionally see milder side effects such as diarrhea, nausea, fatigue, and dry mouth, which usually disappear after stopping the drug.

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Send A Message
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

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