(R)-3-Piperidinamine dihydrochloride/ Alogliptin intermediate 334618-23-4

99% up by HPLC

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Product Details

Product Information

Product name	(R)-3-Piperidinamine dihydrochloride; Alogliptin intermediate
CAS No.	334618-23-4
Molecular Formula	C₅H₁₄Cl₂N₂
Molecular Weight	136.625
Molecular Structure
Quality Standard	99% up by HPLC
Appearance	White or off-white powder

COA

ANALYSIS	SPECIFICATION	RESULTS
Appearance	White or off-white powder	White powder
Identification	NMR：The HNMR spectrum conforms to structure	Conforms
Identification	IR：The IR spectrum conforms to reference substance	Conforms
Purity by GC Each single impurity	> 99.0% < 0.2%	99.6% 0.1% (Max)
Purity by HPLC Each single impurity	> 99.0% < 0.2%	99.9% 0.1%
e e by HPLC(derivative)	> 99.2%	100.0%
Water content by KF	< 0.5%	0.06%
Loss on drying	< 0.5%	0.2%
Residue on ignition	< 0.3%	0.07%
Specific optical rotation	-2士1° (C=4, H20)	[α]D/20=-1.9°
Heavy metals - Pd - Ni	< 20 ppm < 10 ppm	< 20 ppm < 10 ppm
Conclusion	The product meets specification

Usage

What is (R)-3-Piperidinamine dihydrochloride?

(R)-3-Piperidinamine dihydrochloride is one of key intermediates of Alogliptin (API). Alogliptin is used together with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. Alogliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin.