Sinoway Industrial Co., Ltd.

Rivaroxaban 366789-02-8 Rivaroxaban 366789-02-8

Rivaroxaban 366789-02-8
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Basic information of Rivaroxaban :

Name

Rivaroxaban

Alias

(S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV;Rivaroxaban Isomer;5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide;BAY 59-7939; 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide

CAS NO.

366789-02-8

Molecular Formula

C19H18ClN3O5S

Molecular Weight

435.88

Brief Introduction

Rivaroxaban is an oral, bioavailable Factor Xa inhibitor that selectively blocks the active site of Factor Xa and does not require a cofactor (eg, antithrombin III) to exert activity. Activation of factor X by factor Xa (FXa) by endogenous and exogenous pathways plays an important role in the coagulation cascade.

Rivaroxaban dose-dependently inhibits factor Xa activity in humans, with dose-dependent prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), and HepTest® heparin quantitative determination using Neoplastin® reagent. Anti-factor Xa activity is also affected by rivaroxaban.

Storage condition

Room temperature, seal.


Use of Rivaroxaban:

Adult patients undergoing elective hip or knee replacement surgery to prevent venous thromboembolism (VTE)

COA of Rivaroxaban :

Items

Standard

Results

Appearance

White or almost white powder

White powder

Melting point

229~ 234℃

230.0~231.5℃

Residue on ignition

NMT0.1%

0.03%

Related substances


Any other impurity: NMT0.2%

Total of impurity: NMT0.5 %

0.1%

0.19%

Loss on drying

NMT1.0%

0.13%

Heavy metal

NMT20ppm

Conforms

Purity

More than 99.50%

99.81%

Conclusion: The results show that the product complies with the Enterprise standard.



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MORE_DETAIL Rivaroxaban 366789-02-8

Basic information of Rivaroxaban :

Name

Rivaroxaban

Alias

(S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV;Rivaroxaban Isomer;5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide;BAY 59-7939; 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide

CAS NO.

366789-02-8

Molecular Formula

C19H18ClN3O5S

Molecular Weight

435.88

Brief Introduction

Rivaroxaban is an oral, bioavailable Factor Xa inhibitor that selectively blocks the active site of Factor Xa and does not require a cofactor (eg, antithrombin III) to exert activity. Activation of factor X by factor Xa (FXa) by endogenous and exogenous pathways plays an important role in the coagulation cascade.

Rivaroxaban dose-dependently inhibits factor Xa activity in humans, with dose-dependent prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), and HepTest® heparin quantitative determination using Neoplastin® reagent. Anti-factor Xa activity is also affected by rivaroxaban.

Storage condition

Room temperature, seal.


Use of Rivaroxaban:

Adult patients undergoing elective hip or knee replacement surgery to prevent venous thromboembolism (VTE)

COA of Rivaroxaban :

Items

Standard

Results

Appearance

White or almost white powder

White powder

Melting point

229~ 234℃

230.0~231.5℃

Residue on ignition

NMT0.1%

0.03%

Related substances


Any other impurity: NMT0.2%

Total of impurity: NMT0.5 %

0.1%

0.19%

Loss on drying

NMT1.0%

0.13%

Heavy metal

NMT20ppm

Conforms

Purity

More than 99.50%

99.81%

Conclusion: The results show that the product complies with the Enterprise standard.


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