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Lamivudine 134678-17-4 Lamivudine 134678-17-4

Lamivudine 134678-17-4
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Basic information of Lamivudine 134678-17-4

  • CAS No.: 134678-17-4
  • Other Names: 3TC; 4-AMINO-1-((2R,5S)-2-HYDROXYMETHYL-[1,3]OXATHIOLAN-5-YL)-1H-PYRIMIDIN-2-ONE
  • Molecular Formula: C8H11N3O3S
  • Molecular Weight: 229.25
  • Specification: USP
  • Purity: 99% up
  • Appearance: White to off-white crystalline powder, White to off-white crystalline powder
  • Water: Not more than 0.2%
  • Total impurities: Not more than 0.6%
  • Assay: Not less than 98.0% and not more than 102.0%

Usage of Lamivudine 134678-17-4

  • Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir and Epivir-HBV. Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.

COA of Lamivudine 134678-17-4

ASSAY ITEMS

SPECIFICATION(USP)

Appearance

White to off-white crystalline powder

Solubility

Soluble in water, sparingly soluble in ethanol, practically insoluble in ethyl acetate

Light Absorption

Not more than 0.0015 (440nm, 4cm cell, 50mg/ml)

Identification

A) The IR Spectrum of test sample corresponds to the standard IR spectrum of Lamivudine

B) The retention time of the major peak in the chromatogram of the test solution corresponds to that in chromatogram of the reference solution, as obtained in the test of Limit of Lamivudine enantiomer.

Water

Not more than 0.2%

Limit of Lamivudine Enantiomer

Not more than 0.3%

Residual Solvents

Ethanol is not more than 0.2%

Triethylamine (TEA) is not more than 0.1%

Dichloromethane is not more than 0.06%

Toluene is not more than 0.089%

N,N-Dimethylformamide is not more than 0.088%

n-Hexane is not more than 0.029%

Total residual solvents not more than 0.3%

Chromatographic Purity

Salicylic acid is not more than 0.10%

Relative retention time at about 0.4 impurity is not more than 0.3%

Relative retention time at about 0.9 impurity is not more than 0.2%

Any other individual impurity is not more than 0.1%

Total impurities

not more than 0.6%

HPLC Assay (Anhydrous basis)

Not less than 98.0% and not more than 102.0%


MORE_DETAIL Lamivudine 134678-17-4

Basic information of Lamivudine 134678-17-4

  • CAS No.: 134678-17-4
  • Other Names: 3TC; 4-AMINO-1-((2R,5S)-2-HYDROXYMETHYL-[1,3]OXATHIOLAN-5-YL)-1H-PYRIMIDIN-2-ONE
  • Molecular Formula: C8H11N3O3S
  • Molecular Weight: 229.25
  • Specification: USP
  • Purity: 99% up
  • Appearance: White to off-white crystalline powder, White to off-white crystalline powder
  • Water: Not more than 0.2%
  • Total impurities: Not more than 0.6%
  • Assay: Not less than 98.0% and not more than 102.0%

Usage of Lamivudine 134678-17-4

  • Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir and Epivir-HBV. Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.

COA of Lamivudine 134678-17-4

ASSAY ITEMS

SPECIFICATION(USP)

Appearance

White to off-white crystalline powder

Solubility

Soluble in water, sparingly soluble in ethanol, practically insoluble in ethyl acetate

Light Absorption

Not more than 0.0015 (440nm, 4cm cell, 50mg/ml)

Identification

A) The IR Spectrum of test sample corresponds to the standard IR spectrum of Lamivudine

B) The retention time of the major peak in the chromatogram of the test solution corresponds to that in chromatogram of the reference solution, as obtained in the test of Limit of Lamivudine enantiomer.

Water

Not more than 0.2%

Limit of Lamivudine Enantiomer

Not more than 0.3%

Residual Solvents

Ethanol is not more than 0.2%

Triethylamine (TEA) is not more than 0.1%

Dichloromethane is not more than 0.06%

Toluene is not more than 0.089%

N,N-Dimethylformamide is not more than 0.088%

n-Hexane is not more than 0.029%

Total residual solvents not more than 0.3%

Chromatographic Purity

Salicylic acid is not more than 0.10%

Relative retention time at about 0.4 impurity is not more than 0.3%

Relative retention time at about 0.9 impurity is not more than 0.2%

Any other individual impurity is not more than 0.1%

Total impurities

not more than 0.6%

HPLC Assay (Anhydrous basis)

Not less than 98.0% and not more than 102.0%

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