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Candesartan cilexetil 145040-37-5

Candesartan cilexetil 145040-37-5

99% up by HPLC
  • Product Details

Product Information


Product name

Candesartan cilexetil

CAS No.

145040-37-5

Molecular Formula

C33H34N6O6

Molecular Weight

610.66

Quality Standard

99% up, Medicine Grade

Appearance

White powder


COA of Candesartan cilexetil


Items

Specifications

Results

Appearance

A white or almost white powder

White powder

Identification-IR

Complies with the reference spectrum

Complies

Identification- UV

Maximal  absorptions   at    254nm,

minimum absorption at 242nm

Complies

Water

≤ 0.3%

0.19%

Residual solvents

Methanol

≤ 3000ppm

Not found

Ethanol

≤ 5000ppm

Not found

Ethyl ether

≤ 5000ppm

68ppm

Acetone

≤ 5000ppm

482ppm

Ethyl acetate

≤ 5000ppm

Not found

Dichloromethane

≤ 600ppm

Not found

Dimethylformamide

≤ 880ppm

Not found

Related substances

Impurity A

≤ 0.15%

< 0.05%

Impurity B

≤ 0.3%

< 0.05%

Impurity F

≤ 0.2%

< 0.05%

Impurity G

≤ 0.2%

< 0.05%

Impurity H

≤ 0.15%

Not found

Other individual impurity

≤ 0.10%

0.04%

Total impurities

≤ 0.6%

0.21%

Sulfated ash

≤ 0.1%

0.06%

Heavy metals

≤ 10ppm

<10ppm

Assay (Dried substance)

99.0~101.0%

99.8%

Conclusion:

The product complies with EP 9.0



Usage


Function of Candesartan cilexetil
Candesartan cilexetil is an angiotensin II receptor antagonist, also referred to as an ARB drug for short. Candesartan cilexetil is currently recognized as a first-line treatment for hypertension. Candesartan cilexetil tablets can bind to the AT1 receptor of vascular smooth muscle, thereby antagonizing the vasoconstriction effect of angiotensin II and reducing the resistance of peripheral blood vessels.

Among the similar ARB drugs, candesartan cilexetil has the strongest receptor affinity, so it has a longer binding time, so it is a long-acting angiotensin II receptor antagonist, which can be administered once every 24 hours. Can play a stable, long-lasting and effective antihypertensive effect. Not only that, studies have found that candesartan cilexetil can also improve fibrinolytic activity, promote the recovery of vascular endothelial function, and help protect cardiovascular and cerebrovascular other than blood pressure.

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Send A Message
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

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