Sinoway Industrial Co., Ltd.

Emtricitabine 143491-57-0 Emtricitabine 143491-57-0

Emtricitabine 143491-57-0
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Basic information of Emtricitabine

Name

Emtricitabine

Alias

Entricitabine;FTC;4-Amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one;
EMTRITABINE;EMTRICITABIN;SM-Q;

CAS NO.

143491-57-0

Molecular Formula

C8H10FN3O3S

Molecular Weight

247.247

Quality Standard

99% min

Grade Standard

Medicine grade

Package Size

25kg/drum

Use of Emtricitabine

Emtricitabine is a novel nucleoside reverse transcriptase inhibitor, an antiviral drug with antiviral activity against HIV-1, HIV-2 and HBV. Its antiviral activity is manifested in its specific anti-HIV activity. -1, HIV-2 and HBV, and its drug is raised to 100 mnol/L, and it has not been seen for HSV-1, HSV-2, HCMV, VZV, corona, yellow fever virus, respiratory syncytial virus, Rota Influenza virus or rhinovirus shows activity. Even at submicromolar concentrations, the drug showed potent inhibitory effects on HIV-1 LAV and IIIB strains and HIV-2 ROD2 and ZY strains, with IC50 values 95 times lower than AZT (Zidovudine).

COA of Emtricitabine

Item

Requirements

Test Results

Description

A white or almost white crystalline powder

white crystalline powder

Solubility

Freely soluble in Methanol and Water; Practically insoluble in

Dichloromethane

Complies

Identification

The infrared absorption spectrum is

concordant with the spectrum

obtained from Emtricitabine RS or

with the reference spectrum of

Emtricitabine

Complies

 

Determine the Specific Optical Rotation using a 

2.5 mg/ml solution in water R and calculate with reference to the 

dried substance;

 [α]D20 °C = -105.0° to -115.0°.

-107.5°

Limit of Emtricitabine

 Enantiomer

≤0.30%

Not detected

Loss on Drying

≤0.5%   (3 hours at 105°C)

0.14%

Residue on Ignition

≤0.1%

Complies

Related 

Substance

 

Any impurity before the principal   Peak   ≤0.5%

Complies

Not more than 2 impurities over 0.1%  before the principal peak

Complies

Any impurity after the principal peak  ≤0.7%

Complies

Not more than 2 impurities over 0.1%  after the principal peak

Complies

Total impurities   ≤1.0%

0.10%

 


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MORE_DETAIL Emtricitabine 143491-57-0

Basic information of Emtricitabine

Name

Emtricitabine

Alias

Entricitabine;FTC;4-Amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one;
EMTRITABINE;EMTRICITABIN;SM-Q;

CAS NO.

143491-57-0

Molecular Formula

C8H10FN3O3S

Molecular Weight

247.247

Quality Standard

99% min

Grade Standard

Medicine grade

Package Size

25kg/drum

Use of Emtricitabine

Emtricitabine is a novel nucleoside reverse transcriptase inhibitor, an antiviral drug with antiviral activity against HIV-1, HIV-2 and HBV. Its antiviral activity is manifested in its specific anti-HIV activity. -1, HIV-2 and HBV, and its drug is raised to 100 mnol/L, and it has not been seen for HSV-1, HSV-2, HCMV, VZV, corona, yellow fever virus, respiratory syncytial virus, Rota Influenza virus or rhinovirus shows activity. Even at submicromolar concentrations, the drug showed potent inhibitory effects on HIV-1 LAV and IIIB strains and HIV-2 ROD2 and ZY strains, with IC50 values 95 times lower than AZT (Zidovudine).

COA of Emtricitabine

Item

Requirements

Test Results

Description

A white or almost white crystalline powder

white crystalline powder

Solubility

Freely soluble in Methanol and Water; Practically insoluble in

Dichloromethane

Complies

Identification

The infrared absorption spectrum is

concordant with the spectrum

obtained from Emtricitabine RS or

with the reference spectrum of

Emtricitabine

Complies

 

Determine the Specific Optical Rotation using a 

2.5 mg/ml solution in water R and calculate with reference to the 

dried substance;

 [α]D20 °C = -105.0° to -115.0°.

-107.5°

Limit of Emtricitabine

 Enantiomer

≤0.30%

Not detected

Loss on Drying

≤0.5%   (3 hours at 105°C)

0.14%

Residue on Ignition

≤0.1%

Complies

Related 

Substance

 

Any impurity before the principal   Peak   ≤0.5%

Complies

Not more than 2 impurities over 0.1%  before the principal peak

Complies

Any impurity after the principal peak  ≤0.7%

Complies

Not more than 2 impurities over 0.1%  after the principal peak

Complies

Total impurities   ≤1.0%

0.10%

 

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