Prednisolone 50-24-8

97% up by HPLC, EP8/USP38/BP2014

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Product Information

Product name	Prednisolone
CAS No.	50-24-8
Molecular Formula	C₂₁H₂₈O₅
Molecular Weight	360.444
Quality Standard	97% up by HPLC, EP8/USP38/BP2014
Appearance	White powder

COA of Prednisolone

Items	Specifications	Results
Appearance	White or almost white crystalline powder	White crystalline powder
Identification	A;B	Meets test
Specific rotation	+97°~+103°	+99°
Chromatogram purity	Any peak≤1.0% Only one peak＞0.50% Total≤2.0%	Epi-prednisolone＜0.05% Hydrocortisone: 0.79% 11-Deoxypredmosolone＜0.05% Other detected imputiry: RRT (0.81) 0.06% Total: 0.85%
Loss on drying	≤0.5%	0.1%
Residue on ignition	Negligible	Negligible
Selenium	≤0.003%	＜0.003%
Residual solvents	Methanol≤700ppm Methylene chloride≤600ppm	29ppm 507ppm
Assay	97.0~102.0% (on dried substance)	99.0%
Conclusion	It conforms to USP38
Micronized	≤15μm＞80%;≤30μm＞98%

Usage

Function of Prednisolone

Prednisolone is an adrenal cortex hormone drug. Super-physiological glucocorticoids have a variety of pharmacological effects such as anti-inflammatory, anti-allergic and immune suppression.

1. Anti-inflammatory effects: glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the performance of inflammation.

2. Immunosuppressive effects: prevent or inhibit cell-mediated immune responses, delayed allergic reactions, reduce the number of T lymphocytes and monocyte eosinophils, reduce the binding ability of immunoglobulins and cell surface receptors, and inhibit interleukins Synthesis and release, thereby reducing the transformation of T cells to lymphoblasts, and reducing the expansion of the primary immune response.

3. Anti-toxic and anti-shock effects: Glucocorticoids can counteract the stimulating response of bacterial endotoxins to the body, reduce cell damage, and play a role in protecting the body.

*Products under the patent are only for R&D use