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Prednisolone 50-24-8

Prednisolone 50-24-8

97% up by HPLC, EP8/USP38/BP2014
  • Product Details

Product Information


Product name

Prednisolone

CAS No.

50-24-8

Molecular Formula

C21H28O5

Molecular Weight

360.444

Quality Standard

97% up by HPLC, EP8/USP38/BP2014

Appearance

White powder


COA of Prednisolone


Items

Specifications

Results

Appearance

White or almost white crystalline powder

White crystalline powder

Identification

A;B

Meets test

Specific rotation

+97°~+103°

+99°

Chromatogram purity

Any peak1.0%

Only one peak0.50%

Total2.0%

Epi-prednisolone0.05%

Hydrocortisone: 0.79%

11-Deoxypredmosolone0.05%

Other detected imputiry: RRT (0.81) 0.06%

Total: 0.85%

Loss on drying

0.5%

0.1%

Residue on ignition

Negligible

Negligible

Selenium

0.003%

0.003%

Residual solvents

Methanol700ppm

Methylene chloride600ppm

29ppm

507ppm

Assay

97.0~102.0%

(on dried substance)

99.0%

Conclusion

It conforms to USP38

Micronized

15μm80%;30μm98%


Usage


Function of Prednisolone

Prednisolone is an adrenal cortex hormone drug. Super-physiological glucocorticoids have a variety of pharmacological effects such as anti-inflammatory, anti-allergic and immune suppression.

1. Anti-inflammatory effects: glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the performance of inflammation.

2. Immunosuppressive effects: prevent or inhibit cell-mediated immune responses, delayed allergic reactions, reduce the number of T lymphocytes and monocyte eosinophils, reduce the binding ability of immunoglobulins and cell surface receptors, and inhibit interleukins Synthesis and release, thereby reducing the transformation of T cells to lymphoblasts, and reducing the expansion of the primary immune response.

3. Anti-toxic and anti-shock effects: Glucocorticoids can counteract the stimulating response of bacterial endotoxins to the body, reduce cell damage, and play a role in protecting the body.

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