The brain is a highly dependent organ on continuous blood flow. Local cerebral blood flow also increases when neurons in the brain activate strongly. Normally, there is a neurovascular regulation mechanism in brain tissues, which closely coordinates nerve activity with hemodynamics to ensure the oxygen and energy required by the brain to maintain normal physiological activities. The aging of cerebrovascular endothelium is not only associated with dysfunction, but also with Vascular Damentia. There is growing evidence that impaired vascular function can lead to age-related cognitive impairment and dementia.
To verify whether NMN
can treat/prevent neurovascular dysfunction and cognitive impairment in elderly patients, Zoltan Ungvari and his team conducted experimental studies published in June in the Journal Edox Biology.
The experiment mainly draws the following three conclusions:
1. NMN can ameliorate aging-induced vascular endothelial dysfunction and improve NVC response.
2. NMN can reduce mitochondrial ROS in brain microvascular endothelial cells of aged mice and restore NAD + and mitochondrial energy.
3. By improving the NVC, NMN can improve the cognition of aged mice.