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Metformin Hydrochloride 1115-70-4

Metformin Hydrochloride 1115-70-4

98.5% up, EP/USP/BP
  • Product Details

Product Information


Product name

Metformin Hydrochloride; Metformin HCL

Molecular Formula

C4H12CIN5

Molecular Weight

165.62

CAS No.

1115-70-4

Quality Standard

98.5% -101.0%, EP/USP/BP Medical Grade

Appearance

White powder


COA of Metformin Hydrochloride


Tests

Specifications

Results

Appearance

White crystal

White crystal

Identifications

IR: complies with reference spectrum <197k>

Identification test: it meets the requirements of the test for chloride <191>

Conforms

Related compounds

Cyanogunadine (Imp.A)≤0.02%

Any other impurity≤0.1%

Total impurities≤0.5%

0.001%

0.004%

0.01%

Heavy metals

≤0..001%<231>

<0.001%

Loss on drying

≤0.5%<731>

0.05%

Residue on ignition

≤0.1%<281>

0.03%

Residual solvents

Methanol≤3000ppm

380ppm

Assay (on anhydrous basis)

98.5% ~ 101.0%

99.8%

Conclusion: Conforms with USP37


Usage


Function of Metformin Hydrochloride

Metformin hydrochloride is a hypoglycemic drug, which is commonly used by patients with type II diabetes. At present, it is the first-line hypoglycemic drug recommended by Chinese guidelines and foreign guidelines. The main pharmacological effect is to inhibit liver glucose output and improve peripheral tissues’ insulin resistance. Sensitivity to glucose, increase glucose uptake and standby, so as to reduce blood sugar, metformin can reduce glycosylated hemoglobin by 1%-2%. In addition, metformin does not increase weight and does not cause hypoglycemia when used alone. This is also a relatively large advantage of metformin in terms of safety. Studies in recent years have shown that metformin has other effects besides lowering blood sugar, such as improving blood lipids, lowering triglyceride and cholesterol levels, and also reducing platelet aggregation, so it is beneficial to delay or improve vascular complications in diabetic patients . Metformin also has the effect of suppressing appetite, and many obese patients are more suitable to use metformin for weight loss. In short, metformin is a relatively effective drug for lowering blood sugar.

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