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Isavuconazole 241479-67-4

Isavuconazole 241479-67-4

  • Product Details

Product Information


Product name

Isavuconazole

CAS No.

241479-67-4

Molecular Formula

C22H17F2N5OS

Molecular Weight

437.473

Molecular Structure


Quality Standard

98% up by HPLC

Appearance

White to yellow powder


COA of Isavuconazole

ITEMS

STANDARDS

RESULTS

Appearance

White to yellow powder

Conforms

Identification

The peak position of T001-M9 in the test solution was the same as that in the related solution.

Conforms

Solubility

Practically insoluble in watersoluble

Conforms

Melting point

120~126

121.5~123.0

Specific Optical Rotation

[α]D20-25.0°~-34.0°

-29.1°

Related substances

Any single impurity0.5%

0.17%

Total impurity 1.0%

0.23%

Loss on drying

1.0%

0.09%

Assay

98%

99.77%

Conclusion

The above items have been tested according with the Enterprise Standard for the productthe results comply with Specifications .


Usage


Isavuconazole is a new type of triazole antifungal drug. On the basis of retaining the potent anti-Candida activity of the first-generation triazole drugs, it has enhanced the activity against filamentous fungal infection and is a broad-spectrum antifungal drug. Compared with other azoles, the special molecular structure of isavuconazole sulfate (containing 2 chiral centers) enables the orientation of the triazole ring to engage with the binding pocket of the fungal CYP51 protein, thus giving it a broader antifungal spectrum , including fungi resistant to azoles (such as itraconazole, voriconazole, and posaconazole), have good antibacterial activity.

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