Idebenone 58186-27-9

98.5% up by HPLC

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Product Details

Product Information

Product name	Idebenone
CAS No.	58186-27-9
Molecular Formula	C19H30O5
Molecular Weight	338.444
Molecular Structure
Quality Standard	98.5% up by HPLC
Appearance	Orange to yellow crystalline powder

COA

ANALYSIS	SPECIFICATION	RESULTS
Appearance	Orange to yellow crystalline powder	Conforms
Melting range	52-55℃	Conforms
Loss on drying	≤0.1%	0.02%
Residue on ignition	≤0.1%	0.02%
Heavy metals	≤10ppm	Conforms
Total impurities	≤0.8%	0.20%
Assay (by HPLC)	≥98.5%	99.1%
Residue solventies	Hexane ≤ 0.029%	0.006%
	Methanol ≤ 0.30%	ND
	Toluene ≤ 0.89%	0.0085%
Assay((on dried bases)	98.5% - 101.5%	99.8%
Conclusion	The product meets the standard

Usage

What is Idebenone?

Idebenone (6-[10-hydroxydecil]-2,3-dymethoxy-5-methyl-1,4-benzoquinone) is a quinone analogue, which is used in the treatment of several neurological disorders: Friedreich ataxia (FRDA), mitochondrial encephalomyopathies, senile dementia, and Huntington disease. Idebenone acts as an antioxidant through the action of its quinone ring and diffuses more rapidly than ubiquinone across biological membranes due to the modification of the composition and length of its side chain. Besides being a potent antioxidant, idebenone also functions as an electron transport carrier and has been reported to have various other effects, including stimulation of nerve-growth factor production and blockade of voltage-sensitive calcium channels. Idebenone is rapidly absorbed and has a plasma half-life of 14.9 ± 0.7 h. It crosses the blood–brain barrier. Within 48 h, most of the compound is excreted as metabolites in urine and faeces.