Anti-depressants refer to a group of psychotropic substances mainly used to treat mental disorders characterized by depression. Their difference from the analeptics is that anti-depressants can only eliminate depressive symptoms of the depressed patient, whose mood cannot be improved. Anti-depressants came out in the 1950s. Depressive disorders hadn't had the proper medication before and often relied on the electroshock therapy to be cured. Since the 1950s, anti-depressants have become the preferred treatment for depressed patients, which have largely replaced shock treatment and greatly reduced the number of patients who are requiring the shock therapy. Anti-depressants are a large group of psychotropic substances mainly used to treat depression and various depressive states. There are two common first-generation antidepressants - monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCA). Although due to the rapid development, new drugs have come out one after another, such as venlafaxine and naphthalazodone, selective serotonin (5-HT) reuptake inhibitors are the mainly used drugs and the clinical application of these drugs is also the widest. In addition, the anti-depressive effect of some antipsychotic drugs such as sulpiride, anti-anxiety drugs alprazolam, roller, buspirone and the central stimulant methylphenidate remains controversial.
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