D-Pantethine 16816-67-4

Liquid: 98% up by HPLC, JP16; Powder: 50% up by HPLC

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Product Information

Product name	D-Pantethine
CAS No.	16816-67-4
Molecular Formula	C22H42N4O8S2
Molecular Weight	554.729
Quality Standard	Liquid: 98% up by HPLC, JP16; Powder: 50% up by HPLC
Appearance	Liquid: clear, colorless to pale yellow viscous liquid Powder: Fine powder,good fluidity

COA

Product name: D-Pantethine 98% Liquid

ANALYSIS	SPECIFICATION	RESULTS
Appearance	Clear, colorless to pale yellow viscous liquid	Clear, colorless viscous liquid
Solubility	Miscible with water, with methanol and with ethanol(95%)	Miscible with water, with methanol and with ethanol(95%)
Optical rotation	+15.0°~+18.0°	+15.9°
Identification	A, B, C, D should be positive	Positive
Water	18.0%~22.0%。	20.44%
Residue on Ignition	≤0.1%	0.05%
Heavy metals	≤10ppm	＜10ppm
Arsenic	≤1ppm	＜1ppm
Related substances	·D-Pantothenic Acid ≤0.1%	0.02%
	·Impurity A ≤0.3%	0.16%
	·Impurity B ≤0.5%	0.08%
	·Unknown impurities ≤0.1%	0.04%
	·Total impurities ≤1.0%	0.41%
Chiral isomers	≤0.5%	0.28%
Mercapto compounds	A red color should not be developed	A red color is not developed
Residual solvents	·Methanol ≤0.3%	ND
	·Ethanol ≤0.5%	ND
	·Isopropanol ≤0.5%	ND
	·Dichloromethane ≤0.06%	ND
Assay	≥98.0% (on the dried substance)	99.25%
Bacterial Endotoxins	·Bacteria amount ＜1000cfμ/g； ·Mildew and microzyme amount ＜100cfμ； ·Escherichia coli N.T.	Conforms
Conclusion	The substance Pantethine complies with the Requirements of In House Specifications.

Product name: D-Pantethine 50% Powder

ANALYSIS	SPECIFICATION	RESULTS
Appearance	Fine powder, good fluidity	Conforms
Color	White to off-white	Conforms
Assay	48.0% - 52.0%	50.9%
Water	≤4.0%	3.0%
Heavy metals(Pb)	≤10ppm	Conforms
Arsenic/Cadmium Lead/Mercury	≤1ppm(each one)	Conforms
Escherichia coli	≤100 cfu/g	Negative
Staphylococcus aureus	Negative	Negative
Salmonella	Negative	Negative
Mildew and microzyme amount	≤100 cfu/g	< 10 cfu/g
Microbe amount	≤1000 cfu/g	< 10 cfu/g
Conclusion	The substance Pantethine complies with the Requirements of In House Specifications.

Usage

The application of D-Pantethine?

D-Pantethine, a derivative of Vitamin B5 (pantothenic acid), plays a significant role in both the pharmaceutical and food supplement industries, leveraging its biochemical properties for various health-related benefits.

In the Pharmaceutical Industry

1. Cholesterol and Lipid Management: D-Pantethine is recognized for its potential in managing blood cholesterol levels. It is thought to influence the metabolism of cholesterol and triglycerides, thus helping in the management of lipid profiles. Studies have suggested that it can reduce levels of LDL cholesterol ("bad" cholesterol) and triglycerides, while possibly raising HDL cholesterol ("good" cholesterol).

2. Cardiovascular Health: Linked to its effects on lipid profiles, D-Pantethine is also of interest for cardiovascular health. By assisting in the regulation of cholesterol, it may reduce the risk of cardiovascular diseases, including heart attacks and strokes.

3. Diabetic Neuropathy Treatment: There is some evidence to suggest that D-Pantethine can have beneficial effects on diabetic neuropathy, a condition characterized by nerve damage due to high blood sugar levels. Its role in glucose metabolism and vascular health might underlie these effects.

4. Metabolic Syndrome: Given its effects on lipid and glucose metabolism, D-Pantethine may be beneficial in managing metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and diabetes.

In the Food Supplement Industry

1. Energy Metabolism: As a vitamin B5 derivative, D-Pantethine is essential in the synthesis of coenzyme A (CoA), a critical enzyme in metabolic pathways, including those responsible for the generation of energy from carbohydrates, fats, and proteins. Supplements containing D-Pantethine are often marketed for energy support and metabolic health.

2. Stress Relief and Adrenal Support: Vitamin B5 is known as the "anti-stress" vitamin because of its role in the production of stress-related hormones in the adrenal glands. D-Pantethine supplements are sometimes recommended for supporting adrenal function and managing stress.

3. Skin Health: There is also interest in D-Pantethine for skin health, owing to its role in cellular regeneration and the synthesis of lipids, which are important for the skin’s barrier function. It can be found in some skincare supplements aimed at improving skin health and combating acne.

4. Sport and Exercise Performance: Due to its role in energy metabolism and possibly reducing muscle soreness and improving recovery, D-Pantethine is included in some sports and exercise supplements.

5. General Well-being: As a part of a balanced diet, D-Pantethine can contribute to overall well-being by supporting various biochemical functions essential for good health.