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D-Pantethine 16816-67-4

D-Pantethine 16816-67-4

Liquid: 98% up by HPLC, JP16; Powder: 50% up by HPLC
  • Product Details

Product Information

 

Product name

D-Pantethine

CAS No.

16816-67-4

Molecular Formula

C22H42N4O8S2

Molecular Weight

554.729

Quality Standard

Liquid: 98% up by HPLC, JP16; Powder: 50% up by HPLC

Appearance

Liquid: clear, colorless to pale yellow viscous liquid

Powder: Fine powder,good fluidity

 

COA

 

Product name: D-Pantethine 98% Liquid

ANALYSIS

SPECIFICATION

RESULTS

Appearance

Clear, colorless to pale yellow viscous liquid

Clear, colorless viscous liquid

Solubility

Miscible with water, with methanol and with ethanol(95%)

Miscible with water, with methanol and with ethanol(95%)

Optical rotation

+15.0°~+18.0°

+15.9°

Identification

A, B, C, D should be positive

Positive

Water

18.0%~22.0%

20.44%

Residue on Ignition

0.1%

0.05%

Heavy metals

10ppm

10ppm

Arsenic

1ppm

1ppm

Related substances

·D-Pantothenic Acid 0.1%

0.02%

·Impurity A 0.3%

0.16%

·Impurity B 0.5%

0.08%

·Unknown impurities 0.1%

0.04%

·Total impurities 1.0%

0.41%

Chiral isomers

0.5%

0.28%

Mercapto compounds

A red color should not be developed

A red color is not developed

Residual solvents

·Methanol 0.3%

ND

·Ethanol 0.5%

ND

·Isopropanol 0.5%

ND

·Dichloromethane 0.06%

ND

Assay

98.0% (on the dried substance)

99.25%

Bacterial Endotoxins

·Bacteria amount  1000cfμ/g

·Mildew and microzyme amount 100cfμ;

·Escherichia coli  N.T.

Conforms

Conclusion

The substance Pantethine complies with the Requirements of In House Specifications.

 

Product name: D-Pantethine 50% Powder

ANALYSIS

SPECIFICATION

RESULTS

Appearance

Fine powder, good fluidity

Conforms

Color

White to off-white

Conforms

Assay

48.0% - 52.0%

50.9%

Water

4.0%

3.0%

Heavy metals(Pb)

10ppm

Conforms

Arsenic/Cadmium

Lead/Mercury

1ppm(each one)

Conforms

Escherichia coli

100 cfu/g

Negative

Staphylococcus aureus

Negative

Negative

Salmonella

Negative

Negative

Mildew and microzyme amount

 

100 cfu/g

< 10 cfu/g

Microbe amount

 

1000 cfu/g

< 10 cfu/g

Conclusion

The substance Pantethine complies with the Requirements of In House Specifications.

 

Usage

 

The application of D-Pantethine?


D-Pantethine, a derivative of Vitamin B5 (pantothenic acid), plays a significant role in both the pharmaceutical and food supplement industries, leveraging its biochemical properties for various health-related benefits.

 

In the Pharmaceutical Industry

1. Cholesterol and Lipid Management: D-Pantethine is recognized for its potential in managing blood cholesterol levels. It is thought to influence the metabolism of cholesterol and triglycerides, thus helping in the management of lipid profiles. Studies have suggested that it can reduce levels of LDL cholesterol ("bad" cholesterol) and triglycerides, while possibly raising HDL cholesterol ("good" cholesterol).

2. Cardiovascular Health: Linked to its effects on lipid profiles, D-Pantethine is also of interest for cardiovascular health. By assisting in the regulation of cholesterol, it may reduce the risk of cardiovascular diseases, including heart attacks and strokes.

3. Diabetic Neuropathy Treatment: There is some evidence to suggest that D-Pantethine can have beneficial effects on diabetic neuropathy, a condition characterized by nerve damage due to high blood sugar levels. Its role in glucose metabolism and vascular health might underlie these effects.

4. Metabolic Syndrome: Given its effects on lipid and glucose metabolism, D-Pantethine may be beneficial in managing metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and diabetes.

 

In the Food Supplement Industry

1. Energy Metabolism: As a vitamin B5 derivative, D-Pantethine is essential in the synthesis of coenzyme A (CoA), a critical enzyme in metabolic pathways, including those responsible for the generation of energy from carbohydrates, fats, and proteins. Supplements containing D-Pantethine are often marketed for energy support and metabolic health.

2. Stress Relief and Adrenal Support: Vitamin B5 is known as the "anti-stress" vitamin because of its role in the production of stress-related hormones in the adrenal glands. D-Pantethine supplements are sometimes recommended for supporting adrenal function and managing stress.

3. Skin Health: There is also interest in D-Pantethine for skin health, owing to its role in cellular regeneration and the synthesis of lipids, which are important for the skins barrier function. It can be found in some skincare supplements aimed at improving skin health and combating acne.

4. Sport and Exercise Performance: Due to its role in energy metabolism and possibly reducing muscle soreness and improving recovery, D-Pantethine is included in some sports and exercise supplements.

5. General Well-being: As a part of a balanced diet, D-Pantethine can contribute to overall well-being by supporting various biochemical functions essential for good health.


*Products under the patent are only for R&D use

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