Calcium folinate 1492-18-8

99% up by HPLC, GMP, DMF

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Product Details

Product Information

Product name	Calcium folinate
CAS No.	1492-18-8
Molecular Formula	C20H21N7O7.Ca
Molecular Weight	511.507
Molecular Structure
Quality Standard	99% up by HPLC
Appearance	White or light yellow crystalline powder

COA

ANALYSIS	SPECIFICATION	RESULTS
Appearance	White or light yellow crystalline powder	Conforms
Loss on dying	≤1.0%	0.09%
Residue on ignition	≤0.5%	0.1%
Total impurities	≤1.0%	<0.07%
Single impurity	≤0.5%	0.05%
Assay(by HPLC)	99.0% up	99.7%
Conclusion	The product meets the in-house specification

Usage

What is Calcium folinate?

Calcium folinate (called Folinic acid or calcium leucovorin also) is the calcium salt of 5-formyl tetrahydrofolic acid. It is an active metabolite of folinic acid and an essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.

Folinic acid is a medication used in the treatment of various cancers in combination with 5-FU. It is also commonly used as an antidote to folic acid antagonists such as methotrexate. Folinic acid (leucovorin) is an antidote, chemotherapy modulating agent, and rescue agent for the chemotherapy class of medications.5-FU administration reduces deoxythymidine monophosphate, blocks DNA synthesis, and causes cell death. Calcium folinate stabilizes the complex between 5-FU and thymidylate synthase and thus augments 5-FU cytotoxicity.