In recent years, many experimental studies have shown that β-glucan, which is very beneficial to the physiological functions of the human body, can significantly lower blood sugar, lower blood lipids, and improve immunity. Therefore, the development and research of β-glucan It has been very hot.
β-glucan is a homopolymer of glucose, which is abundant in microorganisms, plants and animals. The glucose units of β-glucans from different sources are linked together in different ways to form a bioactive polymer. The main functions of β-glucan are:
1. Improve the body's immunity and fight infection
Yeast β-glucan has an immunomodulatory effect. It can bind to macrophages in animals to activate macrophages; it can activate T lymphocytes, B lymphocytes, macrophages, natural killer cells (NK), etc. The role of immune enhancers; it can secrete some cytokines that activate immune cells, thereby enhancing the function of the animal’s immune system, so it is used as an immune stimulant; in addition, β-glucan can also activate neutrophils and neutrophils in the gastrointestinal tissues Phagocytes, thereby further activate and influence the "immune-neuro-endocrine" regulatory network, and enhance their anti-infection, anti-stress and cell adaptive protection capabilities.
2. Anti-tumor
Tumor immunotherapy is an important adjuvant therapy after tumor surgery, chemotherapy, and radiotherapy. It has the advantages of strong specificity, broad anti-tumor spectrum, and mild side effects. In recent decades, β-glucan has been widely used in the research of tumor immunotherapy as a natural biological effect modifier. Yeast β-glucan has anti-tumor and anti-infection effects. Studies have shown that this effect is achieved by stimulating the immune system and enhancing the body's ability to resist diseases, rather than directly acting on tumor toxic cells.
3. Anti-radiation, promote hematopoiesis
Anti-radiation effect. The anti-radiation effect of dextran is the result of promoting hematopoietic function. Yeast β-glucan can enhance the production of blood cells, including the production of granulocytes, mononuclear white blood cells and red blood cells, resulting in better recovery from lethal doses of radiation
4. Lower cholesterol and blood fat
Since animals generally cannot synthesize β-glucanase by themselves, the ingested β-glucan cannot be decomposed and can only be absorbed passively in the form of nutrient fibers. These absorbed fibers have the functions of lowering blood lipids and cholesterol. utility. The absorption of β-glucan can increase the viscosity of the intestine, thereby reducing the body’s absorption of cholesterol and promoting excretion; the special spatial structure of β-glucan can promote the release of lipoproteins and fatty acids, and increase the amount of blood in the blood. Molecular lipids are broken down into small molecules, which is conducive to blood clarification and cholesterol reduction.
5. Regulate blood sugar
When β-glucan enters the mouth, it will begin to absorb water and swell. The water-soluble β-glucan will increase the viscosity of food and slow down the emptying of the stomach, thereby increasing the satisfaction during meal and the feeling of fullness after meal, thereby affecting carbohydrate absorption and protecting pancreatic β cells , Repair its lesions, improve its functional characteristics to regulate blood sugar.
6. Antioxidant
Yeast β-glucan has a strong antioxidant effect. It can eliminate free radicals in the body, increase the activity of antioxidant enzymes, prevent peroxide and active oxygen from damaging the body, and improve the body's antioxidant capacity. It is reported that water-soluble yeast glucan can increase the SOD activity in serum, and it is positively correlated with the dose. Yeast β-glucan can reduce the content of malondialdehyde in the liver and increase the activity of glutathione peroxidase.
7. Improve gastrointestinal function and affect intestinal flora
Because there is no enzyme in the human body that degrades β-glucans, they act as natural nutrient fibers. Studies have shown that a high-fiber diet can lower cholesterol and reduce the incidence of chronic diseases such as arthritis and heart disease.
8. Promote wound healing
The essence of wound repair is the repair of homeostasis, which is a very complex physiological process. Under normal circumstances, wound repair requires the mutual orchestration of macrophages, fibroblasts, keratinocytes, wound growth factors, matrix proteins, and matrix repair enzymes among cells of different phenotypes. There are also related literatures that the administration of local or systemic β-glucan can speed up wound healing. The mechanism is to increase the infiltration of macrophages in the wound, thereby promoting the growth of granulation and the deposition of collagen, and at the same time strengthening the wound healing. tensile strength.
9. Anticoagulant effect
After experimental research, it is found that the decisive factor of β-glucan anticoagulation is the basic structure of polysaccharide and the sulfation mode. The mode of action of β-glucans is different from that of heparin. They rely on their own unique structure to regulate the antithrombin AT-III, inhibit the activity of coagulation factor IIa and Xa, and reach different stages that interfere with the coagulation process.
We Sinoway could supply you β-glucan from different source, or customized the β-glucan according your requestments.
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